[基因组不稳定性与肿瘤形成]
[Genome instability and neoplasia].
作者信息
Shapot V S, Mironov N M
出版信息
Tsitol Genet. 1981 Nov-Dec;15(6):73-83.
PMID:6275583
Abstract
Necessity of oncogene for the neoplastic cell transformation is substantiated. The oncogene may be introduced into the cell by a virus; be present in the cell from its formation but be repressed by products of regulatory genes; be arisen from separated DNA segments. The latter possibility is discussed in view of data on the presence of mobile elements and Sarc sequences in the cell genome.
摘要
致癌基因对肿瘤细胞转化的必要性已得到证实。致癌基因可由病毒引入细胞；在细胞形成时就已存在于细胞中，但被调节基因的产物所抑制；由分离的DNA片段产生。鉴于细胞基因组中存在移动元件和Sarc序列的数据，对后一种可能性进行了讨论。
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