压力感受器去传入对大鼠中枢儿茶酚胺的影响。
Effect of baroreceptor deafferentation on central catecholamines in the rat.
作者信息
Petty M A, Chalmers J P, Brown M, Reid J L
出版信息
Clin Sci (Lond). 1979 Dec;57 Suppl 5:221s-223s. doi: 10.1042/cs057221s.
PMID:44231
Abstract
- Sinoaortic deafferentation in the rat leads to increased blood pressure and heart rate. 2. Early increases in tyrosine hydroxylase activity both in brain stem and hypothalamus suggest that increased noradrenaline synthesis may contribute to the development of neurogenic hypertension. 3. After 4 weeks, phenylethanolamine-N-methyltransferase activity was reduced in the hypothalamus. 4. Noradrenaline- and adrenaline, but not dopamine-containing neurones may participate in regulation of sympathetic efferent activity.
摘要
- 大鼠的窦弓反射传入神经切断会导致血压和心率升高。2. 脑干和下丘脑酪氨酸羟化酶活性早期增加表明，去甲肾上腺素合成增加可能有助于神经源性高血压的发展。3. 4周后，下丘脑苯乙醇胺 - N - 甲基转移酶活性降低。4. 去甲肾上腺素能和肾上腺素能神经元（而非多巴胺能神经元）可能参与交感传出活动的调节。
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