SK&F 92657，一种通过毛细血管前血管舒张和β-肾上腺素能受体阻滞发挥作用的新型抗高血压药物。
SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade.
作者信息
Taylor E M, Roe A M, Slater R A
出版信息
Clin Sci (Lond). 1979 Dec;57 Suppl 5:433s-436s. doi: 10.1042/cs057433s.
PMID:44235
Abstract
- The properties of a new antihypertensive agent, SK&F 92657, DL-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The beta-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cadiac stimulation.
摘要
- 已对一种新型抗高血压药物SK&F 92657，即DL-3-[2-(3-叔丁基氨基-2-羟基丙氧基)苯基]-6-肼基哒嗪的性质进行了研究。2. 该化合物由于毛细血管前血管舒张，特别是在肾血管和冠状血管中，导致几种动物的血压持续下降。3. SK&F 92657的β-肾上腺素能受体阻断作用可防止反射性心脏刺激。
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