纤溶酶可激活血浆肾素原，但在酸激活的碱性阶段并非必需。

Plasmin can activate plasma prorenin but is not required for the alkaline phase of acid activation.

Sealey J E, Atlas S A, Laragh J H, Silverberg M, Kaplan A P

Clin Sci (Lond). 1979 Dec;57 Suppl 5:97s-99s. doi: 10.1042/cs057097s.

Abstract

Plasma prorenin is an inactive form of renin that is converted into active renin at alkaline pH in previously acidified plasma; this conversion of prorenin into renin is mediated by Hageman factor-dependent activation of prekallikrein, which, in turn, leads to prorenin activation. 2. Since plasma kallikrein can activate plasminogen, the present studies were designed to evaluate whether alkaline-phase activation of prorenin by plasma kallikrein is mediated via plasminogen activation. 3. We demonstrated that plaminogen is present in acid-treated plasma in sufficient quantity to convert prorenin into renin after activation by streptokinase. 4. However, alkaline-phase activation was completely normal in plasminogen-free plasma. 5. Therefore alkaline-phase activation of plasma prorenin is mediated by plasma kallikrein but is not dependent on kallikrein activation of plasminogen.

摘要

血浆前肾素是肾素的无活性形式，在先前酸化的血浆中于碱性pH条件下转化为活性肾素；前肾素向肾素的这种转化由激肽释放酶原的Hageman因子依赖性激活介导，而这又导致前肾素激活。2. 由于血浆激肽释放酶可激活纤溶酶原，本研究旨在评估血浆激肽释放酶对前肾素的碱性相激活是否通过纤溶酶原激活介导。3. 我们证明，在经酸处理的血浆中存在足够量的纤溶酶原，可在被链激酶激活后将前肾素转化为肾素。4. 然而，在无纤溶酶原的血浆中，碱性相激活完全正常。5. 因此，血浆前肾素的碱性相激活由血浆激肽释放酶介导，但不依赖于激肽释放酶对纤溶酶原的激活。