Stebbings J H
Thorax. 1974 Sep;29(5):505-10. doi: 10.1136/thx.29.5.505.
, , 505-510. The fractional carbon monoxide uptake in 913 New York City transit workers was studied. A prediction equation for white males, based on nonsmokers, was obtained: fractional CO uptake = 0·58032 − 0·00204 × age + 0·0004 × weight (kilograms). Weight was the index of body size most strongly correlated with the fractional CO uptake. Decline in function with age by amount of tobacco smoked is described. A correction factor for respiration, based on results from 581 workers with two or more tests, was calculated: − 0·123654 × (standard tidal volume − observed tidal volume). Tidal volume was the most important contributor to individual variability of the fractional CO uptake, and minute volume or respiration rate do not add significantly to it. For epidemiological or screening uses, prediction equations are given for the fractional CO uptake corrected to 0·5 1. tidal volume. Respiration variables explain only 1·5% of individual variability, and individual variability over a mean period of 16·6 months was much larger (an individual standard error of 0·07) than the unexplained population variability (a population standard error of 0·01−0·02); thus the usefulness of the fractional CO uptake as a test of respiratory function is in doubt.
对913名纽约市公交工作人员的一氧化碳摄取分数进行了研究。基于非吸烟者得出了白人男性的预测方程：一氧化碳摄取分数=0.58032−0.00204×年龄+0.0004×体重（千克）。体重是与一氧化碳摄取分数相关性最强的身体尺寸指标。描述了随着吸烟量增加功能随年龄的下降情况。根据581名接受两次或更多次测试的工作人员的结果计算出呼吸校正因子：−0.123654×（标准潮气量−观察到的潮气量）。潮气量是一氧化碳摄取分数个体变异性的最重要因素，分钟通气量或呼吸频率对其影响不显著。对于流行病学或筛查用途，给出了校正至0.5升潮气量的一氧化碳摄取分数的预测方程。呼吸变量仅解释了1.5%的个体变异性，并且在平均16.6个月期间的个体变异性（个体标准误差为0.07）远大于未解释的总体变异性（总体标准误差为0.01−0.02）；因此，一氧化碳摄取分数作为呼吸功能测试的有用性值得怀疑。
