Pinerua R F, Hartnett B J
Thorax. 1974 Sep;29(5):599-602. doi: 10.1136/thx.29.5.599.
, 599-602. Acute pulmonary reaction to nitrofurantoin is a rare complication of a commonly used drug. This report of such a reaction presents studies of pulmonary function more detailed than are so far available. Studies made nine days after the drug had been withdrawn showed arterial hypoxaemia and abnormalities in ventilation-perfusion relationships. Challenge with 200 mg nitrofurantoin produced increased minute ventilation, hypoxaemia, hypocapnia, deterioration in ventilation-perfusion relationships, marked veno-arterial shunting, and a fall in steady-state transfer factor for carbon monoxide and fractional carbon monoxide uptake. Spirometry and lung volume measurements indicated a restrictive lung abnormality without effect on large airways which persisted for at least nine weeks. Three years later there had been complete resolution of the process, apart from some persistent reduction in transfer factor, possibly related to the patient's smoking habits.
，599 - 602。呋喃妥因引起的急性肺部反应是一种常用药物的罕见并发症。本关于此类反应的报告提供了比迄今可得资料更为详细的肺功能研究。在停药九天后进行的研究显示动脉血氧不足以及通气 - 灌注关系异常。用200毫克呋喃妥因激发试验导致分钟通气量增加、低氧血症、低碳酸血症、通气 - 灌注关系恶化、明显的静脉 - 动脉分流以及一氧化碳稳态转移因子和一氧化碳分数摄取量下降。肺活量测定和肺容积测量表明存在限制性肺异常，对大气道无影响，且这种情况持续了至少九周。三年后，除了转移因子仍有一些持续下降（可能与患者的吸烟习惯有关）外，该过程已完全消退。
