Quinn R W, Lowry P N
Yale J Biol Med. 1974;47(2):86-92.
This study showed that streptococcal L forms could not be isolated from children who were either carriers of group A streptococci or had disease due to this pathogen. It was possible to induce L colony formation in 15 strains of group A. Streptococcal bacteriophages were demonstrated in 20% of group A streptococci isolated from school children who were carriers, but did not have clinical evidence of streptococcal disease, and from 44.9% of children whose physicians considered they had acute streptococcal upper respiratory infections. Lysogeny (bacteriophage) was demonstrated more frequently during 1969-70 when carrier rates were high and from children who had manifest streptococcal disease, suggesting a possible positive relationship between lysogeny, high carrier rates, and infection in the children studied. Lysogeny and erythrogenic toxin production by group A streptococci occurred simultaneously in approximately half of the strains of group A streptococci tested, suggesting that lysogeny is not a sine qua non for erythrogenic toxin production.
本研究表明，从A组链球菌携带者或因该病原体致病的儿童中无法分离出链球菌L型。在15株A组菌株中可诱导形成L菌落。从无症状的A组链球菌携带者学龄儿童及44.9%被医生诊断为患有急性链球菌性上呼吸道感染的儿童中分离出的A组链球菌，有20%检测出链球菌噬菌体。在1969 - 1970年携带者比例较高期间，以及在患有明显链球菌病的儿童中，溶原性（噬菌体）现象更为常见，这表明在所研究的儿童中，溶原性、高携带者比例和感染之间可能存在正相关关系。在大约一半的受试A组链球菌菌株中，溶原性和产红疹毒素同时出现，这表明溶原性并非产红疹毒素的必要条件。
