• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.

作者信息

Gillette J R

出版信息

Biochem Pharmacol. 1974 Nov 1;23(21):2927-38. doi: 10.1016/0006-2952(74)90267-6.

DOI:10.1016/0006-2952(74)90267-6
PMID:4429593
Abstract
摘要

相似文献

1
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.对外源化合物化学反应性代谢产物在毒性中作用的一种观点。II. 共价结合动力学的改变
Biochem Pharmacol. 1974 Nov 1;23(21):2927-38. doi: 10.1016/0006-2952(74)90267-6.
2
The role of biotransformation in chemical-induced liver injury.生物转化在化学性肝损伤中的作用。
Environ Health Perspect. 1976 Jun;15:27-38. doi: 10.1289/ehp.761527.
3
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.解毒酶在溴苯诱导的肝坏死中的作用。
J Pharmacol Exp Ther. 1973 Oct;187(1):218-27.
4
Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.述评。对外源化合物化学反应性代谢产物在毒性作用中角色的一种观点。I. 反应性代谢产物共价结合变化与毒性发生率和严重程度变化的相关性。
Biochem Pharmacol. 1974 Oct 15;23(20):2785-94. doi: 10.1016/0006-2952(74)90052-5.
5
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.药物代谢的诱导作用。II. 多环烃和苯巴比妥刺激的微粒体N-脱甲基化系统的定性差异。
Mol Pharmacol. 1969 Mar;5(2):186-99.
6
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.与卤代芳烃代谢产物共价结合相关的小叶中心性肝坏死。
Exp Mol Pathol. 1973 Feb;18(1):80-99. doi: 10.1016/0014-4800(73)90009-9.
7
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.芳香烃诱导肝坏死的生化机制。
Pharmacology. 1973;10(4):193-214. doi: 10.1159/000136440.
8
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.对乙酰氨基酚在大鼠和小鼠离体肝细胞中的代谢与毒性
Biochem Pharmacol. 1978;27(24):2859-63. doi: 10.1016/0006-2952(78)90201-0.
9
Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo.体内肝外组织中活性萘代谢产物的肝内形成、输出及共价结合的证据。
J Pharmacol Exp Ther. 1983 Apr;225(1):8-16.
10
Regulation of glucuronidation and sulfate conjugation in isolated hepatocytes.离体肝细胞中葡萄糖醛酸化和硫酸结合反应的调节
Drug Metab Dispos. 1979 Nov-Dec;7(6):416-9.

引用本文的文献

1
Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future.生物监测人白蛋白加合物:过去、现在与未来
Chem Res Toxicol. 2017 Jan 17;30(1):332-366. doi: 10.1021/acs.chemrestox.6b00366. Epub 2016 Dec 18.
2
Liver cell models in in vitro toxicology.体外毒理学中的肝细胞模型
Environ Health Perspect. 1998 Apr;106 Suppl 2(Suppl 2):511-32. doi: 10.1289/ehp.98106511.
3
Clinical pharmacokinetics of hydralazine.肼屈嗪的临床药代动力学。
Clin Pharmacokinet. 1982 May-Jun;7(3):185-205. doi: 10.2165/00003088-198207030-00001.
4
The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects.化学致癌作用中的阈值问题——关于理论与实践方面的一些观点
J Cancer Res Clin Oncol. 1980;97(1):1-14. doi: 10.1007/BF00411273.
5
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.悬浮状态下的分离大鼠肝细胞:六种不同药物的潜在肝毒性作用
Arch Toxicol. 1984 Nov;56(1):33-7. doi: 10.1007/BF00316349.
6
Anticancer drug pharmacodynamics.抗癌药药效学
Cancer Chemother Pharmacol. 1985;14(3):177-83. doi: 10.1007/BF00258112.
7
Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.代谢活化在化学诱导的肺部疾病发病机制中的作用:肺毒性呋喃4-异戊烯醇的作用机制
Environ Health Perspect. 1976 Aug;16:127-38. doi: 10.1289/ehp.7616127.
8
Oral toxicity of 1,1-dichloroethylene in the rat: effects of sex, age, and fasting.大鼠中1,1 - 二氯乙烯的经口毒性:性别、年龄和禁食的影响
Environ Health Perspect. 1977 Dec;21:157-63. doi: 10.1289/ehp.7721157.
9
Mutagenicity and chromosomal aberrations as an analytical tool for in vitro detection of mammalian enzyme-mediated formation of reactive metabolites.致突变性和染色体畸变作为体外检测哺乳动物酶介导的活性代谢物形成的分析工具。
Arch Toxicol. 1977 Dec 30;39(1-2):159-69. doi: 10.1007/BF00343283.