Schmid W, van der Zypen E, Keller H
Acta Anat (Basel). 1979;104(1):36-51.
The effect of a subtotal vagotomy on the function of the intramural nervous system of different parts of the intestinal tract is studied by means of quantitative measurements of the acetylcholinesterase (AChE) activity. By sham vagotomy it was possible to explore the effect of narcosis and laparotomy on the intramural nervous system of the intestine. Vagotomy is followed by a decrease in AChE activity of the ganglionic cells in all parts of the intestinal tract. A minimum of activity, about 50% of the normal concentration, is attained at the 16th postoperative day. After this time, a continual increase in AChE activity, along with a reactivation of the function of the ganglionic cells, can be observed. 90 days after vagotomy the ganglionic cells of the intramural nervous plexus show a normal enzyme activity. These results support the hypothesis that most of the cells of the myenteric plexus build up an autonomic nervous plexus, which is stimulated in an excitatory way by the vagus nerve and which will be inhibited by sympathetic stimulation.
通过对乙酰胆碱酯酶（AChE）活性进行定量测量，研究了次全迷走神经切断术对肠道不同部位壁内神经系统功能的影响。通过假迷走神经切断术，能够探究麻醉和剖腹手术对肠道壁内神经系统的影响。迷走神经切断术后，肠道各部位神经节细胞的AChE活性均降低。术后第16天达到最低活性，约为正常浓度的50%。此后，可以观察到AChE活性持续增加，同时神经节细胞功能重新激活。迷走神经切断术后90天，壁内神经丛的神经节细胞显示出正常的酶活性。这些结果支持了以下假设：肌间神经丛的大多数细胞构成一个自主神经丛，该神经丛受到迷走神经的兴奋性刺激，并将受到交感神经刺激的抑制。
