左旋多巴治疗慢性肝性脑病
Treatment of chronic hepatic encephalopathy with levodopa.
作者信息
Lunzer M, James I M, Weinman J, Sherlock S
出版信息
Gut. 1974 Jul;15(7):555-61. doi: 10.1136/gut.15.7.555.
Abstract
Three of six patients with chronic hepatic encephalopathy treated with levodopa showed a significant improvement. One patient was probably improved whilst the remaining two patients failed to show any benefit. Serial electroencephalography did not demonstrate significant changes. Treatment with levodopa was associated with an improvement in ;speed-based' tasks as assessed by computerized psychometry. A significant rise in cerebral oxygen consumption was found during levodopa therapy. Gastrointestinal side effects were dose limiting. It is concluded that a therapeutic trial of levodopa in patients with chronic hepatic encephalopathy is indicated when the response to conventional therapy has been poor.
摘要
在接受左旋多巴治疗的6例慢性肝性脑病患者中，有3例病情显著改善。1例患者可能有所好转，而其余2例患者未显示出任何益处。连续脑电图检查未显示出显著变化。根据计算机化心理测试评估，左旋多巴治疗与“基于速度”任务的改善有关。在左旋多巴治疗期间发现脑氧消耗量显著增加。胃肠道副作用限制了剂量。得出的结论是，当对传统治疗反应不佳时，对慢性肝性脑病患者进行左旋多巴治疗试验是有必要的。
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