Crawford D W, Sanmarco M E, Blankenhorn D H
Am J Med. 1979 May;66(5):784-9. doi: 10.1016/0002-9343(79)91117-3.
Reports of atherosclerotic changes in human subjects previously described have been based on evaluation of arteriographic edge contours. They imply unchanged roentgenographic and physiologic conditions, including identical patient positioning and vascular tone which cannot always be obtained in sequential studies. We have previously described the development of quantitative angiographic densitometry which permits measurement of vascular cross-sectional chord length distributions and areas, independent of rotational changes in vascular position. In this paper we report on application of the method to sequential femoral angiograms in two patients in whom there were significant increases in vascular cross-sectional area after a program of exercise and risk reduction. The method excludes interpretive errors due to circumferential changes in vascular tone.
先前描述的关于人类受试者动脉粥样硬化变化的报告是基于对动脉造影边缘轮廓的评估。这些报告暗示了X线造影和生理状况不变，包括相同的患者体位和血管张力，但在连续研究中并非总能实现。我们之前描述了定量血管造影密度测定法的发展，该方法可测量血管横截面弦长分布和面积，而不受血管位置旋转变化的影响。在本文中，我们报告了该方法在两名患者连续股动脉血管造影中的应用，这两名患者在进行了运动和降低风险计划后，血管横截面积显著增加。该方法排除了由于血管张力周向变化导致的解释性误差。
