来自人子宫壁蜕膜的腺苷酸环化酶。

Adenylate cyclase from human decidua parietalis.

作者信息

Whitsett J A, Johnson C L

出版信息

Am J Obstet Gynecol. 1979 Mar 1;133(5):479-83. doi: 10.1016/0002-9378(79)90280-1.

Abstract

Adenylate cyclase (EC 4.6.1.1) activity was demonstrated in membrane fractions of human decidua parietalis. Adenylate cyclase activity was associated with membrane fractions of decidua but not chorion or amnion. Prostaglandins PGE1 and PGE2 but neither PGD2 nor PGF2 alpha stimulated this activity at gestational ages 18 to 40 weeks. Fluoride and guanosine triphosphate stimulated decidual adenylate cyclase; however, epinephrine-stimulated adenylate cyclase activity was demonstrable only in the presence of guanosine triphosphate. The possible roles of adenylate cyclase activity in the decidua are discussed.

摘要

在人子宫壁蜕膜的膜组分中证实了腺苷酸环化酶（EC 4.6.1.1）活性。腺苷酸环化酶活性与蜕膜的膜组分相关，而与绒毛膜或羊膜无关。在妊娠18至40周时，前列腺素PGE1和PGE2可刺激该活性，而PGD2和PGF2α则不能。氟化物和鸟苷三磷酸可刺激蜕膜腺苷酸环化酶；然而，肾上腺素刺激的腺苷酸环化酶活性仅在存在鸟苷三磷酸时才能显示出来。文中讨论了腺苷酸环化酶活性在蜕膜中的可能作用。