血红蛋白贝尔法斯特15（A12）色氨酸突变为精氨酸：一种新的不稳定血红蛋白变体。
Haemoglobin Belfast 15 (A12) tryptophan leading to arginine: a new unstable haemoglobin variant.
作者信息
Kennedy C C, Blundell G, Lorkin P A, Lang A, Lehmann H
出版信息
Br Med J. 1974 Nov 9;4(5940):324-6. doi: 10.1136/bmj.4.5940.324.
Abstract
A new unstable haemoglobin, alpha(2)beta(2)15 Trp--> Arg (Hb Belfast), with increased oxygen affinity has been found during the routine investigation of a long-stay psychiatric patient. It seemed to cause little haematological disorder. The reticulocytes synthesized normal and abnormal beta-chains at the same rate but in the circulating blood Hb Belfast amounted to only 27.5% of the total haemoglobin.
摘要
在对一名长期住院的精神病人进行常规检查时，发现了一种新的不稳定血红蛋白α(2)β(2)15色氨酸→精氨酸（Hb Belfast），其氧亲和力增加。它似乎几乎没有引起血液学紊乱。网织红细胞以相同速率合成正常和异常的β链，但在循环血液中，Hb Belfast仅占总血红蛋白的27.5%。
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