Churchill P C, Malvin R L, Churchill M C, McDonald F D
Am J Physiol. 1979 May;236(5):R297-301. doi: 10.1152/ajpregu.1979.236.5.R297.
Arterial blood pressure, urine flow rate, and plasma and urine electrolytes were measured in the aglomerular goosefish (L. americanus) before, during, and after the intravenous infusion of angiotensin II (from 5 to 280 ng/min.kg body wt). Increases in arterial blood pressure were directly related to the logarithm of the angiotensin infusion rate (r = 0.62, P less than 0.005). Angiotensin also increased urine flow from 0.676 +/- 0.065 to 0.755 +/- 0.068 ml/h.kg body wt (P less than 0.005) and Na excretion from 41.0 +/- 5.5 to 54.4 +/- 7.0 mumol/h.kg body wt (P less than 0.001). In 17 of the 19 fish infused with angiotensin the diuretic and natriuretic effects were directly related to the logarithm of the infusion rate (r = 0.44, P less than 0.04 and r = 0.51, P less than 0.02, respectively). There was no relationship between the pressor and the diuretic or natriuretic effects of angiotensin II. These results are consistent with inhibitory effects of angiotensin on solute transport by aglomerular tubules.
在无肾小球的美洲鮟鱇（L. americanus）静脉输注血管紧张素II（剂量从5至280 ng/min·kg体重）之前、期间及之后，测量其动脉血压、尿流率以及血浆和尿液电解质。动脉血压的升高与血管紧张素输注速率的对数直接相关（r = 0.62，P < 0.005）。血管紧张素还使尿流率从0.676 ± 0.065增加至0.755 ± 0.068 ml/h·kg体重（P < 0.005），钠排泄量从41.0 ± 5.5增加至54.4 ± 7.0 μmol/h·kg体重（P < 0.001）。在19条输注血管紧张素的鱼中，有17条的利尿和排钠作用与输注速率的对数直接相关（分别为r = 0.44，P < 0.04和r = 0.51，P < 0.02）。血管紧张素II的升压作用与利尿或排钠作用之间无关联。这些结果与血管紧张素对无肾小球肾小管溶质转运的抑制作用一致。
