Murray R D, Malvin R L
Am J Physiol. 1979 Jun;236(6):F559-66. doi: 10.1152/ajprenal.1979.236.6.F559.
Autoregulatory responses of renal plasma flow (RPF) and glomerular filtration rate (GFR) to reductions in renal artery pressure (RAP) were studied in both kidneys of two-kidney, one-clamp dogs and in dogs treated with deoxycorticosterone acetate (DOCA; 25 mg/kg) plus high sodium diets with and without renal arterial clamping. In non-DOCA-treated animals, unilateral renal artery constriction resulted in a significant difference (P = 0.004) in renal renin activity (RRA) between the clamped (171 +/- 37 ng AI.mg-1.h-1) and the contralateral (57 +/- 23 mg AI.mg-1.h-1) kidneys with no change in their relative autoregulatory ability. In dogs treated with DOCA/high sodium there were no differences in RRA between the clamped and contralateral kidneys. The dogs treated with DOCA/high sodium were able to autoregulate both RPF and GFR even though their RRA was only 5.4 ng AI.mg-1.h-1. DOCA/high sodium treatment, however, reduced basal RPF (22%) and GFR (23%) below those in non-DOCA-treated animals. Analysis of the autoregulatory ability of individual kidneys showed no relationship to either RRA or renin secretory rates. These results support the conclusion that the renin-angiotensin system is not necessary component in the autoregulation of RPF or GFR.
在双肾单夹狗的双侧肾脏以及用醋酸脱氧皮质酮（DOCA；25毫克/千克）加高钠饮食处理且有或无肾动脉夹闭的狗身上，研究了肾血浆流量（RPF）和肾小球滤过率（GFR）对肾动脉压（RAP）降低的自身调节反应。在未用DOCA处理的动物中，单侧肾动脉狭窄导致夹闭肾（171±37纳克血管紧张素I·毫克⁻¹·小时⁻¹）和对侧肾（57±23毫克血管紧张素I·毫克⁻¹·小时⁻¹）之间的肾素活性（RRA）有显著差异（P = 0.004），而它们的相对自身调节能力无变化。在用DOCA/高钠处理的狗中，夹闭肾和对侧肾之间的RRA无差异。尽管在用DOCA/高钠处理的狗中其RRA仅为5.4纳克血管紧张素I·毫克⁻¹·小时⁻¹，但它们仍能够对RPF和GFR进行自身调节。然而，DOCA/高钠处理使基础RPF（22%）和GFR（23%）低于未用DOCA处理的动物。对单个肾脏自身调节能力的分析表明，其与RRA或肾素分泌率均无关系。这些结果支持这样的结论，即肾素 - 血管紧张素系统不是RPF或GFR自身调节的必要组成部分。
