从卓-艾氏肿瘤组织中分离出两种小胃泌素。
Isolation of two minigastrins from Zollinger-Ellison tumour tissue.
作者信息
Gregory R A, Tracy H J
出版信息
Gut. 1974 Sep;15(9):683-5. doi: 10.1136/gut.15.9.683.
Abstract
A pair of gastrin tridecapeptides (;minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. The proportion of types I and II is approximately 2:1 similar to that for the ;big' gastrins and the heptadecapeptides isolated from the same source and from human antral mucosa. Both minigastrins are potent stimulants of gastric acid secretion. Immunological evidence exists to indicate that both are present as circulating forms of the hormone gastrin in patients with the Zollinger-Ellison syndrome and in fed normal subjects.
摘要
已从佐林格-埃利森肿瘤组织中分离出一对胃泌素十三肽（“迷你胃泌素”）；它们对应于从同一来源分离出的十七肽的5-17片段。其中一种（II型）存在的酪氨酸残基被硫酸化，另一种（I型）则未被硫酸化。I型和II型的比例约为2:1，与从同一来源和人胃窦黏膜中分离出的“大”胃泌素和十七肽的比例相似。两种迷你胃泌素都是胃酸分泌的强效刺激物。有免疫学证据表明，在佐林格-埃利森综合征患者和进食后的正常受试者中，两者均以胃泌素激素的循环形式存在。
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本文引用的文献
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Isolation of two gastrins from human antral mucosa.
Nature. 1966 Feb 5;209(5023):583. doi: 10.1038/209583a0.
2
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3
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Gastroenterology. 1971 Feb;60(2):203-14.
4
Size and charge distinctions between endogenous human plasma gastrin in peripheral blood and heptadecapeptide gastrins.外周血中内源性人血浆胃泌素与十七肽胃泌素之间的大小和电荷差异。
Gastroenterology. 1970 May;58(5):609-15.
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J Biol Chem. 1971 May 10;246(9):2842-8.
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7
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10
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