Twietmeyer T A, Maynard J A, Bhalla R C
Angiology. 1979 May;30(5):317-26. doi: 10.1177/000331977903000505.
Samples of aortae and caudal arteries from normotensive and hypertensive rats were studied for cytochemical and biochemical determinations of acid and alkaline phosphatase activities. Cytochemical examination revealed an increased amount of acid phosphatase reaction product in hypertensive samples, with extensive localization to the extracellular matrix. Alkaline phosphatase activity was localized to the plasma membrane of fibroblasts and vascular smooth muscle cells and to the extracellular matrix. Biochemical assays of enzyme activities supported the cytochemical findings, showing increased activity in aortae from hypertensive rats.
对正常血压和高血压大鼠的主动脉和尾动脉样本进行了酸性和碱性磷酸酶活性的细胞化学及生化测定研究。细胞化学检查显示，高血压样本中酸性磷酸酶反应产物的量增加，且广泛定位于细胞外基质。碱性磷酸酶活性定位于成纤维细胞和血管平滑肌细胞的质膜以及细胞外基质。酶活性的生化测定结果支持了细胞化学研究结果，表明高血压大鼠主动脉中的活性增加。
