Baudin G, Wahba W K, Casellas D, Mimran A
Ann Biol Clin (Paris). 1979;37(1):7-10.
When rats are submitted to diets with variable sodium, concentration, one may observe a significant increase in the excretion of urinary kallikrein and in the kallikrein activity of the renal tissue in animals in chronic sodium depletion. During experimental renovascular hypertension induced in the rat by stenosis of the renal artery, one may note a significant rise in the excretion of urinary kallikrein; no change in this excretion is observed when the stenosis is associated with nephrectomy on the opposite side. It is possible to consider interrelations between the renin-angiotensin-aldosterone system and the kallikrein-kinin system.
当给大鼠喂食钠浓度不同的饮食时，人们可能会观察到，在慢性缺钠的动物中，尿激肽释放酶的排泄及肾组织中激肽释放酶的活性会显著增加。在通过肾动脉狭窄诱导大鼠产生实验性肾血管性高血压的过程中，人们可能会注意到尿激肽释放酶的排泄显著增加；当狭窄与对侧肾切除术同时进行时，未观察到这种排泄有变化。肾素-血管紧张素-醛固酮系统与激肽释放酶-激肽系统之间的相互关系是可以考虑的。
