Bureau M A, Fecteau C, Patriquin H, Rola-Pleszczynski M, Masse S, Begin R
Am Rev Respir Dis. 1979 Apr;119(4):671-5. doi: 10.1164/arrd.1979.119.4.671.
A 5-year-old child with classic farmer's lung disease is reported. The disease started after a flulike episode and progressed during 3 months to severe respiratory failure. The clinical features were fatigability, weight loss, recurrent fever, dry cough, pulmonary rales, and clubbing. Serologic studies for precipitins to Micropolyspora faeni were positive. The chest roentgenogram showed a ground-glass appearance with air bronchogram. The open lung biopsy material was typical for alveolitis, with minute interstitial granulomas and obliteration of lung parenchyma. The child's condition improved rapidly with prednisone therapy and avoidance of the allergen.
报告了一名患典型农民肺疾病的5岁儿童。该病始于一次流感样发作后,在3个月内进展为严重呼吸衰竭。临床特征为疲劳、体重减轻、反复发热、干咳、肺部啰音和杵状指。针对嗜热放线菌的沉淀素血清学研究呈阳性。胸部X线片显示磨玻璃样外观伴空气支气管征。开胸肺活检材料为典型的肺泡炎,有微小的间质肉芽肿和肺实质闭塞。患儿经泼尼松治疗并避免接触过敏原后病情迅速改善。