Peillon F, Bard H, Mowszowicz I, Cesselin F, Lagoguey M, Boyet F
Ann Endocrinol (Paris). 1979 Jan-Feb;40(1):73-4.
The pituitary gonadal-axis has been studied in 25 cases of PRL-secreting adenomas in men. Besides impotence, infertility, arrest or lack of puberty may be observed, basal levels of LH and FSH are in the low normal range but a weak increase of LH is observed after LH-RH. Testosterone (T) levels are low in most of the patients and only normal in 5. In two cases with actively secreting-PRL adenomas, normal circadian rhythms of T and PRL are abolished. After CB 154 treatment, an improvement of the clinical and biological symptoms is observed in 8 out of 10 men. An increase of LH response to LH-RH under CB 154 is obtained in 5 cases. This is in favour of a functional effect of the hyperprolactinemia on the pituitary.
对25例男性泌乳素分泌型腺瘤患者的垂体性腺轴进行了研究。除了阳痿外，还可观察到不育、青春期停滞或缺乏，促黄体生成素（LH）和促卵泡生成素（FSH）的基础水平处于低正常范围，但在注射促性腺激素释放激素（LH-RH）后LH有轻度升高。大多数患者的睾酮（T）水平较低，只有5例正常。在2例泌乳素腺瘤分泌活跃的患者中，T和PRL的正常昼夜节律被消除。在10名男性中，有8名在接受溴隐亭（CB 154）治疗后，临床和生物学症状有所改善。5例患者在CB 154作用下，LH对LH-RH的反应增强。这支持高泌乳素血症对垂体的功能影响。
