Martinez L R, Holland S, Fitzgerald J, Kountz S
Resuscitation. 1979;7(2):109-17. doi: 10.1016/0300-9572(79)90005-4.
We investigated the effect of repeated administration of sodium bicarbonate on acid-base balance and serum chemistry in a group of patients who developed cardiac arrest. A mixed acidosis persisted throughout the duration of resuscitation in the majority of patients in spite of the large ventilatory volume and multiple doses of bicarbonate they received. However, the repeated administration of bicarbonate prevented a severe fall in serum pH. Our study demonstrated the beneficial role of bicarbonate in the treatment of metabolic acidosis associated with cardiac arrest of prolonged duration. Analysis of our data strongly indicated that the primary factors which determine the serum pH during cardiopulmonary resuscitation are the duration of circulatory arrest, adequacy of ventilation and circulation, pH immediately before arrest, and quantity of bicarbonate administered and its volume of distribution in the various fluid and tissue compartments.
我们研究了反复给予碳酸氢钠对一组发生心脏骤停患者酸碱平衡及血清化学指标的影响。尽管大多数患者在复苏过程中接受了大量通气量和多剂碳酸氢钠治疗，但混合性酸中毒在复苏期间持续存在。然而，反复给予碳酸氢钠可防止血清pH值严重下降。我们的研究证明了碳酸氢钠在治疗与长时间心脏骤停相关的代谢性酸中毒中的有益作用。对我们数据的分析有力地表明，在心肺复苏期间决定血清pH值的主要因素是循环骤停的持续时间、通气和循环的充分性、骤停前的pH值、给予的碳酸氢钠量及其在各种体液和组织间隙中的分布容积。
