Conversion of carcinogens related to 7,12-dimethylbenz(a)anthracene by rat liver homogenates to the carcinogenic metabolite 7-hydroxymethyl-12-methylbenz(a)anthracene.
作者信息
Couch R C, Fields K B, Flesher J W
出版信息
Res Commun Chem Pathol Pharmacol. 1974 Oct;9(2):279-89.
PMID:4438833
Abstract
摘要
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1
Conversion of carcinogens related to 7,12-dimethylbenz(a)anthracene by rat liver homogenates to the carcinogenic metabolite 7-hydroxymethyl-12-methylbenz(a)anthracene.大鼠肝脏匀浆将与7,12-二甲基苯并(a)蒽相关的致癌物转化为致癌代谢物7-羟甲基-12-甲基苯并(a)蒽。
Res Commun Chem Pathol Pharmacol. 1974 Oct;9(2):279-89.
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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.芳香多环烃的环氧衍生物。与7,12-二甲基苯并(a)蒽相关的环氧化物的制备与代谢。
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Studies on the metabolism of 7-methylbenz-[a]anthracene and 7,12-dimethylbenz[1]anthracene and its hydroxymethyl derivatives in rat liver and adrenal homogenates.7-甲基苯并[a]蒽和7,12-二甲基苯并[a]蒽及其羟甲基衍生物在大鼠肝脏和肾上腺匀浆中的代谢研究。
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The formation of dihydrodiols by the chemical or enzymic oxidation of 7-hydroxymethyl-12-methylbenz[alpha]anthracene and the possible role of hydroxymethyl dihydrodiols in the metabolic activation of 7,12-dimethylbenz[alpha]anthracene.7-羟甲基-12-甲基苯并[a]蒽经化学或酶促氧化形成二氢二醇以及羟甲基二氢二醇在7,12-二甲基苯并[a]蒽代谢活化中的可能作用。
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