Goel K M, Shanks R A
Arch Dis Child. 1974 Nov;49(11):861-6. doi: 10.1136/adc.49.11.861.
Five cases of scleroderma in childhood have been reviewed. All presented with cutaneous complaints. Raynaud's phenomenon occurred in 2 and Sjögren's syndrome in one. A patient with linear scleroderma and hemiatrophy developed subcutaneous calcification 5 years after the onset of disease. Of the 5 patients reviewed, 2 have been clinically well for several years, while the disease is progressive in the remaining 3. Because of the clinical and serological overlap, confusion is possible between dermatomyositis, scleroderma, juvenile rheumatoid arthritis, and systemic lupus erythematosus, particularly when these connective tissue disorders are so uncommon in children. It appears that scleroderma in children may be less severe than in adults and that systemic involvement is less common. The presence of Raynaud's phenomenon, antinuclear factor, lupus erythematosus (LE) cells, and a raised erythrocyte sedimentation rate indicate a poor prognosis.
回顾了5例儿童硬皮病病例。所有病例均以皮肤症状就诊。2例出现雷诺现象，1例出现干燥综合征。1例患有线状硬皮病和半侧萎缩的患者在疾病发作5年后出现皮下钙化。在回顾的5例患者中，2例临床状况良好已数年，而其余3例病情呈进行性发展。由于临床和血清学表现存在重叠，皮肌炎、硬皮病、幼年类风湿关节炎和系统性红斑狼疮之间可能会出现混淆，尤其是当这些结缔组织疾病在儿童中如此罕见时。儿童硬皮病似乎可能比成人病情较轻，且系统性受累情况较少见。出现雷诺现象、抗核因子、红斑狼疮（LE）细胞以及红细胞沉降率升高提示预后不良。
