苯并[a]芘代谢产物-核苷加合物在离体灌注大鼠和小鼠肝脏及小鼠肺切片中的形成。 - Suppr

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超能文献

Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices.

作者信息

Kahl G F, Klaus E, Legraverend C, Nebert D W, Pelkonen O

出版信息

Biochem Pharmacol. 1979 Apr 1;28(7):1051-6. doi: 10.1016/0006-2952(79)90302-2.

DOI:10.1016/0006-2952(79)90302-2

PMID:444261

Abstract

摘要

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Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices.苯并[a]芘代谢产物-核苷加合物在离体灌注大鼠和小鼠肝脏及小鼠肺切片中的形成。

Biochem Pharmacol. 1979 Apr 1;28(7):1051-6. doi: 10.1016/0006-2952(79)90302-2.

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by aryl hydrocarbon hydroxylase inducers.芳烃羟化酶诱导剂对体内苯并(a)芘代谢产物与DNA之间加合物形成的抑制作用。

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In vitro benzo[a]pyrene metabolism from lindane-treated rat liver: effect of oral and acute administration, and comparison with phenobarbital and methylcholanthrene pretreatment.林丹处理的大鼠肝脏体外苯并[a]芘代谢：口服和急性给药的影响，以及与苯巴比妥和甲基胆蒽预处理的比较。

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A benzo[alpha]pyrene-7,8-dihydrodiol-9,10-epoxide is the major metabolite involved in the binding of benzo[alpha]pyrene to DNA in isolated viable rat hepatocytes.苯并[a]芘-7,8-二氢二醇-9,10-环氧化物是苯并[a]芘在分离的活大鼠肝细胞中与DNA结合所涉及的主要代谢产物。

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The formation of benzo [a] pyrene - deoxyribonucleoside adducts in vivo and in vitro.

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Effects of phenobarbital, 3-methylcholanthrene and beta-naphthoflavone pretreatment on mouse liver microsomal enzymes and on metabolite patterns of benzo[a]pyrene.苯巴比妥、3-甲基胆蒽和β-萘黄酮预处理对小鼠肝脏微粒体酶及苯并[a]芘代谢物模式的影响。

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Binding of benzo(a)pyrene metabolites to cellular DNA in perfused rat lungs.苯并(a)芘代谢产物与灌注大鼠肺细胞DNA的结合。

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Nuclear metabolism of benzo(a)pyrene and of (+/-)-trans-7-8-dihydroxy-7-8,-dihydrobenzo(a)pyrene. Comparative chromatographic analysis of alkylated DNA.苯并（a）芘和（±）-反式-7,8-二羟基-7,8-二氢苯并（a）芘的核代谢。烷基化DNA的比较色谱分析。

Arch Biochem Biophys. 1977 Sep;183(1):31-7. doi: 10.1016/0003-9861(77)90415-5.

Biochem Biophys Res Commun. 1982 Mar 30;105(2):596-602. doi: 10.1016/0006-291x(82)91476-0.

引用本文的文献

Effect of selected induction of microsomal and nuclear aryl hydrocarbon monooxygenase and epoxide hydrolase as well as cytoplasmic glutathione S-epoxide transferase on the covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo.微粒体和细胞核芳烃单加氧酶、环氧化物水解酶以及细胞质谷胱甘肽S-环氧化物转移酶的特定诱导对致癌物苯并(a)芘在体内与大鼠肝脏DNA共价结合的影响。

J Cancer Res Clin Oncol. 1980;98(2):139-52. doi: 10.1007/BF00405958.

Role of cytochrome P-450 and related enzymes in the pulmonary metabolism of xenobiotics.细胞色素P-450及相关酶在外源化学物肺代谢中的作用。

Environ Health Perspect. 1984 Apr;55:359-67. doi: 10.1289/ehp.8455359.

Covalent binding of BP-metabolites to DNA of cultured human hair follicle keratinocytes.BP代谢产物与培养的人毛囊角质形成细胞DNA的共价结合。

Arch Toxicol. 1985 Apr;57(1):6-12. doi: 10.1007/BF00286567.

Comparison of benzo(a)pyrene metabolism in isolated perfused rat lung and liver.离体灌注大鼠肺和肝脏中苯并(a)芘代谢的比较。

Arch Toxicol. 1987 Jun;60(4):270-7. doi: 10.1007/BF01234665.

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