Sutherland J M, Hooper W D, Eadie M J, Tyrer J H
J Neurol Neurosurg Psychiatry. 1974 Oct;37(10):1116-20. doi: 10.1136/jnnp.37.10.1116.
The rate of disappearance of ergotamine from the mouth after buccal administration has been studied in seven subjects. Allowance has been made for non-absorptive losses of the drug due to experimental technique. The absorption of ergotamine across the buccal mucosa appears to be a passive process, pH-dependent but independent of ergotamine concentration or the simultaneous presence of caffeine. Because of the low solubility of ergotamine at the pH of saliva, it is unlikely that therapeutically useful amounts of the drug would have absorbed across the buccal mucosa even after the drug had been in the mouth for five minutes.
对7名受试者进行了颊部给药后麦角胺从口腔消失速率的研究。已考虑到实验技术导致的药物非吸收性损失。麦角胺经颊黏膜的吸收似乎是一个被动过程，依赖于pH值，但与麦角胺浓度或咖啡因的同时存在无关。由于麦角胺在唾液pH值下的溶解度较低，即使药物在口腔中停留5分钟后，治疗有效量的药物也不太可能经颊黏膜吸收。
