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Plasma concentrations of diphenylhydantoin, its para-hydroxylated metabolite, and corresponding glucuronide in man.

作者信息

Albert K S, Hallmark M R, Sakmar E, Weidler D J, Wagner J G

出版信息

Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):463-9.

PMID:4445566
Abstract
摘要

相似文献

1
Plasma concentrations of diphenylhydantoin, its para-hydroxylated metabolite, and corresponding glucuronide in man.人体内二苯妥英、其对羟基化代谢产物及相应葡糖醛酸苷的血浆浓度。
Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):463-9.
2
Quantitative separation of diphenylhydantoin and its para-hydroxylated metabolites by high-performance liquid chromatography.采用高效液相色谱法对二苯乙内酰脲及其对羟基化代谢物进行定量分离。
Res Commun Chem Pathol Pharmacol. 1973 Nov;6(3):845-54.
3
A gas chromatographic/mass spectrometric method for the simultaneous quantitation of 5,5-diphenylhydantoin (phenytoin), its para-hydroxylated metabolite and their stable isotope labelled analogs.
Clin Chim Acta. 1981 Sep;115(3):263-75. doi: 10.1016/0009-8981(81)90240-0.
4
Protein binding of phenytoin, p-hydroxy phenytoin, and p-hydroxy phenytoin glucuronide.苯妥英、对羟基苯妥英和对羟基苯妥英葡萄糖醛酸苷的蛋白结合情况。
J Clin Pharmacol. 1986 Nov-Dec;26(8):677-9. doi: 10.1002/j.1552-4604.1986.tb02971.x.
5
Evidence for an arene oxide-NIH shift pathway in the metabolic conversion of phenytoin to 5-(4-hydroxyphenyl)-5-phenylhydantoin in the rat and in man.
Drug Metab Dispos. 1982 Nov-Dec;10(6):667-71.
6
Direct high-performance liquid chromatographic analysis of p-hydroxyphenyl-phenylhydantoin glucuronide, the final metabolite of phenytoin, in human serum and urine.
J Chromatogr. 1990 Apr 6;526(2):581-9. doi: 10.1016/s0378-4347(00)82544-x.
7
Comparative study on the para-metabolic oxidation of phenytoin and decadeuteriophenytoin.
Arzneimittelforschung. 1990 Oct;40(10):1076-8.
8
Hydantoin ring glucuronidation: characterization of a new metabolite of 5,5-diphenylhydantoin in man and the rat.
Biomed Mass Spectrom. 1977 Aug;4(4):275-9. doi: 10.1002/bms.1200040415.
9
Analysis of mephenytoin, 4-hydroxymephenytoin and 4-hydroxyphenytoin enantiomers in human urine by cyclodextrin micellar electrokinetic capillary chromatography: simple determination of a hydroxylation polymorphism in man.环糊精胶束电动毛细管色谱法分析人尿中美芬妥因、4-羟基美芬妥因和4-羟基苯妥英对映体：简便测定人体中的羟基化多态性
Electrophoresis. 1994 Jan;15(1):87-93. doi: 10.1002/elps.1150150113.
10
Inhibition of diphenylhydantoin elimination by its major metabolite.
Res Commun Chem Pathol Pharmacol. 1972 Sep;4(2):297-306.

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Formation of active metabolites of anticonvulsant drugs. A review of their pharmacokinetic and therapeutic significance.抗惊厥药物活性代谢物的形成。其药代动力学及治疗意义综述。
Clin Pharmacokinet. 1991 Jul;21(1):27-41. doi: 10.2165/00003088-199121010-00003.