Taylor J F, Ziegler J L
Br J Cancer. 1974 Oct;30(4):312-8. doi: 10.1038/bjc.1974.198.
Defects in cellular immunocompetence have been sought in 25 patients with Kaposi's sarcoma. Skin tests with recall antigens, and PHA lymphocyte stimulation in vitro showed that efferent delayed hypersensitivity responses are intact in the majority. However, attempted sensitization and subsequent challenge with DNCB demonstrated that the afferent limb of the responses was impaired in some patients. This did not appear to be related to the morphology of the tumour or to prognosis.Tumour specific reactions were demonstrated both in vivo and in vitro and these correlated significantly with the morphology and histology. The interpretation of the results for an individual is confounded by the multiplicity of factors influencing the outcome in a particular patient.
对25例卡波西肉瘤患者的细胞免疫能力缺陷进行了研究。用回忆抗原进行皮肤试验以及体外PHA淋巴细胞刺激试验表明，大多数患者的传出性迟发型超敏反应是完整的。然而，用二硝基氯苯进行致敏尝试及随后的激发试验表明，部分患者反应的传入支受损。这似乎与肿瘤的形态或预后无关。体内和体外均证实了肿瘤特异性反应，且这些反应与形态学和组织学显著相关。在个体中对结果的解释因影响特定患者结局的多种因素而变得复杂。
