溴苄铵对大鼠心脏微粒体部分内源性及新合成去甲肾上腺素的作用。
The effect of bretylium on endogenous and newly-synthesized noradrenaline in the microsomal fraction of rat heart.
作者信息
Abbs E T, Pycock C J
出版信息
Br J Pharmacol. 1974 Apr;50(4):606-8. doi: 10.1111/j.1476-5381.1974.tb08597.x.
Abstract
Bretylium reduced the content of endogenous and newly-synthesized noradrenaline (NA) and also reduced the specific activity of NA in the microsomal fraction of rat heart. Bretylium also decreased the endogenous NA content of the microsomal subfraction which equilibrated in the 0.7 M sucrose region of a density gradient; it was without effect on the NA content of other subfractions.
摘要
溴苄铵降低了内源性和新合成的去甲肾上腺素（NA）的含量，同时也降低了大鼠心脏微粒体部分中NA的比活性。溴苄铵还降低了在密度梯度的0.7M蔗糖区域达到平衡的微粒体亚组分的内源性NA含量；它对其他亚组分的NA含量没有影响。
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Selective depletion of noradrenaline: a proposed mechanism of the adrenergic neurone-blocking action of bretylium.去甲肾上腺素的选择性耗竭：一种关于溴苄铵肾上腺素能神经元阻断作用的推测机制。
Br J Pharmacol. 1970 Apr;38(4):776-91. doi: 10.1111/j.1476-5381.1970.tb09887.x.
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The effects of bretylium on the subcellular distribution of noradrenaline and on adrenergic nerve function in rat heart.溴苄铵对大鼠心脏去甲肾上腺素亚细胞分布及肾上腺素能神经功能的影响。
Br J Pharmacol. 1973 Sep;49(1):11-22. doi: 10.1111/j.1476-5381.1973.tb08263.x.
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