溴苄铵对大鼠心脏微粒体部分内源性及新合成去甲肾上腺素的作用。
The effect of bretylium on endogenous and newly-synthesized noradrenaline in the microsomal fraction of rat heart.
作者信息
Abbs E T, Pycock C J
出版信息
Br J Pharmacol. 1974 Apr;50(4):606-8. doi: 10.1111/j.1476-5381.1974.tb08597.x.
Abstract
Bretylium reduced the content of endogenous and newly-synthesized noradrenaline (NA) and also reduced the specific activity of NA in the microsomal fraction of rat heart. Bretylium also decreased the endogenous NA content of the microsomal subfraction which equilibrated in the 0.7 M sucrose region of a density gradient; it was without effect on the NA content of other subfractions.
摘要
溴苄铵降低了内源性和新合成的去甲肾上腺素（NA）的含量，同时也降低了大鼠心脏微粒体部分中NA的比活性。溴苄铵还降低了在密度梯度的0.7M蔗糖区域达到平衡的微粒体亚组分的内源性NA含量；它对其他亚组分的NA含量没有影响。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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The release of catechol amines by choline 2,6-XYLYL ether, bretylium and guanethidine.胆碱2,6-二甲苯基醚、溴苄铵和胍乙啶对儿茶酚胺的释放作用。
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Light and heavy norepinephrine storage particles in the rat heart and in bovine splenic nerve.大鼠心脏和牛脾神经中的轻、重去甲肾上腺素储存颗粒。
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Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.交感神经刺激期间猫脾脏中新合成去甲肾上腺素的选择性释放。
J Pharmacol Exp Ther. 1968 Jun;161(2):271-8.
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The storage of endogenous noradrenaline in sympathetic nerve terminals.内源性去甲肾上腺素在交感神经末梢中的储存。
J Physiol. 1971 May;215(1):163-79. doi: 10.1113/jphysiol.1971.sp009463.
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Selective depletion of noradrenaline: a proposed mechanism of the adrenergic neurone-blocking action of bretylium.去甲肾上腺素的选择性耗竭：一种关于溴苄铵肾上腺素能神经元阻断作用的推测机制。
Br J Pharmacol. 1970 Apr;38(4):776-91. doi: 10.1111/j.1476-5381.1970.tb09887.x.
7
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Philos Trans R Soc Lond B Biol Sci. 1971 Jun 17;261(839):319-23. doi: 10.1098/rstb.1971.0063.
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