肝渗透压感受器？
Hepatic osmoreceptors?
作者信息
Glasby M A, Ramsay D J
出版信息
J Physiol. 1974 Dec;243(3):765-76. doi: 10.1113/jphysiol.1974.sp010776.
Abstract
- The effects of 0.45% saline infusions into the portal vein of conscious and anaesthetized dogs have been compared with similar infusions through a systemic vein.2. Measurements were made of plasma and urinary osmolality, sodium, potassium and chloride concentrations and urine flows; osmolal clearances, free water clearances, the percentage of the infused loads excreted at given times, and rates of sodium and potassium excretion in the urine, were calculated.3. In the conscious and anaesthetized series of experiments no significant differences were found between the portal and systemic routes of infusion.4. For both the portal and systemic routes of infusion there was a significantly smaller diuretic response to the saline infusion in anaesthetized as compared with conscious animals.5. These results do not support the concept of hepatic osmoreceptors occurring in the dog.
摘要
已将0.45%盐水输注到清醒和麻醉犬的门静脉中的效果与通过体静脉进行的类似输注进行了比较。
测量了血浆和尿渗透压、钠、钾和氯浓度以及尿流量；计算了渗透清除率、自由水清除率、在给定时间排泄的输注负荷百分比以及尿中钠和钾的排泄率。
在清醒和麻醉的实验系列中，未发现门静脉和体静脉输注途径之间存在显著差异。
对于门静脉和体静脉输注途径，与清醒动物相比，麻醉动物对盐水输注的利尿反应明显较小。
这些结果不支持犬存在肝渗透压感受器的概念。
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Hepatic osmoreceptors?肝渗透压感受器？
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本文引用的文献
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Lack of evidence for a hepatic osmoreceptor mechanism in conscious dogs.
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