Mizushima Y, Ishikawa M
Nihon Yakurigaku Zasshi. 1979 Nov;75(8):799-804.
Betamethasone 17, 21-dipropionate (BDP) does not have glycogenic activity and antagonizes cortisol in glycogenesis in fetal rat liver explants. In an attempt to elucidate whether BDP commonly has an antagonistic effect on the glucocorticoid responsive system in fetal rat liver, effects on activities of glycogen synthase and tyrosine aminotransferase were examined. Cortisol increased both total and a activities of glycogen synthase at concentrations above 3 x 10(-8)M. BDP, unlike cortisol, did not increase total synthase activity at 10(-6)M and antagonized cortisol (10(-6)M), but like cortisol, it did increase synthase a activity. Both cortisol and BDP increased tyrosine aminotransferase activity at concentrations above 10(-8)M, BDP did not always act as an antagonist in the glucocorticoid responsive systems in fetal rat liver.
倍他米松17,21 - 二丙酸酯（BDP）不具有糖原生成活性，并且在胎鼠肝脏外植体的糖原生成过程中拮抗皮质醇。为了阐明BDP是否通常对胎鼠肝脏中的糖皮质激素反应系统具有拮抗作用，研究了其对糖原合酶和酪氨酸转氨酶活性的影响。皮质醇在浓度高于3×10^(-8)M时会增加糖原合酶的总活性和a活性。与皮质醇不同，BDP在10^(-6)M时不会增加总合酶活性，并且拮抗皮质醇（10^(-6)M），但与皮质醇一样，它确实会增加合酶a活性。皮质醇和BDP在浓度高于10^(-8)M时都会增加酪氨酸转氨酶活性，BDP在胎鼠肝脏的糖皮质激素反应系统中并不总是起拮抗剂的作用。
