Nawalinski T A, Schad G A
Am J Trop Med Hyg. 1974 Sep;23(5):895-8. doi: 10.4269/ajtmh.1974.23.895.
The course of self-induced infection with about 100 Ancylostoma duodenale larvae was followed by twice-weekly blood and stool examinations. After a small initial increase, no further change in eosinophil counts occurred until the 33rd week of infection when they began to increase sharply. Seven weeks later, eggs were first observed in stools. Thus, in this infection, the prepatent period was five times the expected. It is suggested that a strain of A.duodenale exists which either 1) has an inherent, abnormally long prepatent period or 2) has a prepatent period which is susceptible to change depending upon the environmental conditions experienced by the free-living larvae. In either case, the third stage larvae probably enter a hypobiotic state within the host which lasts for about 8 months.
用约100条十二指肠钩虫幼虫进行自体感染，通过每周两次的血液和粪便检查来跟踪感染过程。在最初有少量增加之后，嗜酸性粒细胞计数没有进一步变化，直到感染第33周时才开始急剧增加。7周后，首次在粪便中观察到虫卵。因此，在这种感染中，潜伏期是预期的5倍。有人认为，存在一种十二指肠钩虫菌株，要么1）具有内在的、异常长的潜伏期，要么2）其潜伏期易受自由生活幼虫所经历的环境条件影响而发生变化。无论哪种情况，第三期幼虫可能在宿主体内进入一种持续约8个月的休眠状态。
