Gauld L W, Hanson R P, Thompson W H, Sinha S K
Am J Trop Med Hyg. 1974 Sep;23(5):983-92. doi: 10.4269/ajtmh.1974.23.983.
Ecological studies were conducted to document the role of the eastern chipmunk (Tramias striatus) as a vertebrate host for La Crosse (LAC) virus in nature during late summer when Aedes triseriatus mosquitoes are most abundant. Movement, home range and density of chipmunk populations were determined by trap mark and recapture techniques on grid study areas. The temporal distribution of A. triseriatus was estimated by use of oviposition traps. Passive antibodies were found in spring-born juveniles captured prior to mid-July and in summer-born juveniles in September. Active antibodies neutralizing LAC virus were first detected in susceptible chipmunks in mid-July and 68 free-living and 4 sentinel animals developed antibodies during the study. Virus transmission continued at a high rate through August but was not detected in September. Chipmunk habitat was ranked for quality and populations of chipmunks. A. triseriatus were more abundant in study areas with most suitable chipmunk habitat. Populations of A. triseriatus were temporally associated with the elaboration of antibodies in chipmunks. In one study area, antibody prevalence rates in adult and spring-born juveniles reached 100% by September. Findings implicate A. triseriatus as the vector and establish chipmunks as important amplifying hosts in discontinuous foci of virus transmission.
开展了生态学研究，以记录东部花栗鼠（Tamias striatus）在夏末自然界中作为拉克罗斯（LAC）病毒脊椎动物宿主的作用，此时三带喙库蚊最为常见。通过在网格研究区域使用陷阱标记和重捕技术，确定了花栗鼠种群的活动、活动范围和密度。利用产卵陷阱估计了三带喙库蚊的时间分布。在7月中旬之前捕获的春季出生的幼崽以及9月捕获的夏季出生的幼崽中发现了被动抗体。中和LAC病毒的活性抗体于7月中旬首次在易感花栗鼠中检测到，在研究期间，68只自由生活的动物和4只哨兵动物产生了抗体。病毒传播在8月一直保持较高速率，但在9月未检测到。对花栗鼠栖息地的质量和花栗鼠种群进行了排名。在花栗鼠栖息地最适宜的研究区域，三带喙库蚊更为常见。三带喙库蚊的种群在时间上与花栗鼠体内抗体的产生有关。在一个研究区域，到9月时，成年花栗鼠和春季出生的幼崽的抗体流行率达到了100%。研究结果表明三带喙库蚊是传播媒介，并确定花栗鼠是病毒传播不连续疫源地中的重要扩增宿主。
