头孢噻吩在人体胆道中的药理学。
Pharmacology of cephalothin in the biliary tract of humans.
作者信息
Mendelson J, Portnoy J, Sigman H, Dick V
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):659-65. doi: 10.1128/AAC.6.6.659.
Abstract
Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic.
摘要
对大量患者测定了头孢噻吩的血清和胆道水平。在39名受试者中，仅4名（10.3%）在单次服用抗生素后1小时血清头孢噻吩水平处于治疗范围。仅2.4%的受试者达到了治疗性胆汁头孢噻吩水平，且这一情况发生在抗生素给药后40至70分钟之间。
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