双苯并咪唑治疗小鼠淋巴细胞性脉络丛脑膜炎病毒感染的评估。
Evaluation of bis-benzimidazoles in the treatment of murine lymphocytic choriomeningitis virus infections.
作者信息
Stella J P, Michaelson J, Dorfman S L, Morgan J H, Pfau C J
出版信息
Antimicrob Agents Chemother. 1974 Dec;6(6):754-6. doi: 10.1128/AAC.6.6.754.
Abstract
Seventy percent of the mice receiving (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethandiol (A36683) in their drinking water lived at least four times longer than control mice when infected with 10 or 100 mean lethal doses of lymphocytic choriomeningitis virus strain UBC. In the next 4 months, most of the survivors died with lymphocytic choriomeningitis-like symptoms. Drug treatment during the first 7 days after infection was found to have no significant effect on virus titers in various organs. The sparing effect of the drug is discussed in terms of immunosuppression.
摘要
在饮用水中摄入(S,S)-1,2-双(5-甲氧基-2-苯并咪唑基)-1,2-乙二醇(A36683)的小鼠中，70%在感染10或100个平均致死剂量的淋巴细胞性脉络丛脑膜炎病毒UBC株时，存活时间比对照小鼠长至少四倍。在接下来的4个月里，大多数幸存者死于类似淋巴细胞性脉络丛脑膜炎的症状。研究发现，感染后前7天进行药物治疗对各器官中的病毒滴度没有显著影响。从免疫抑制的角度讨论了该药物的保护作用。
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