Kawakami M, Akema T, Ando S
Brain Res. 1979 Jun 22;169(2):287-301. doi: 10.1016/0006-8993(79)91031-x.
The present study was performed in an attempt to elucidate the possible neural networks and their functional modification by progesterone among estrogen and progesterone effective brain areas for lordosis behavior of the rat. Single and multiple unit activities were recorded in the medial preoptic area (MPO), dorsomedial thalamic nucleus (MD), interpeduncular nucleus (IP) and ventral part of midbrain reticular formation (MRF), and single or train pulse stimulation was applied to the MPI, MD, IP, MRF, caudate-putamen (CP), habenular nucleus (HB), dorsal hippocampus (HPC), medial and lateral septum (m- and 1-SEPT) and lateral amygdala (1-AMYG). Unit activity was recorded under urethane anesthesia in ovariectomized rats pretreated with estrogen or with estrogen and progesterone. MPO units showed facilitatory responses to stimulation in the MRF, HB and 1-SEPT, and inhibitory responses to stimulation in the MD, HPC, m-SEPT and 1-AMYG in ovariectomized estrogen-primed rats. CP stimulation inhibited the MD unit activity. Stimulation in the IP had no effect on the MPO or MD units, while the IP units were affected by stimulation in the MPO, MD, CP and HB. MRF unit was accelerated by the MD and CP and inhibited by the MPO stimulation. In the ovariectomized, estrogen and progesterone-treated rat, the MPO unit responses to the MRF and MD stimulation, and the MD unit responses to the MRF and CP stimulation were different from those in the rat with only estrogen treatment. In addition, in the ovariectomized estrogen-primed rat, local application of progesterone to the MD prevented the inhibitory effect of the MD on the MPO unit. Progesterone, when given to the stimulated brain area, accelerated the MPO unit which was activated by the MRF stimulation, and inhibited the MD neuron which was inhibited by the CP stimulation. Multiple unit recordings showed similar results. Moreover, multi-unit activity in the HB and IP was elevated following a systemic progesterone application. On the basis of these results, the possible neural networks in the brain which participate in the lordosis control mechanisms are discussed.
本研究旨在阐明大鼠脊柱前凸行为的雌激素和孕激素有效脑区中，可能的神经网络及其受孕激素影响的功能变化。记录内侧视前区（MPO）、背内侧丘脑核（MD）、脚间核（IP）和中脑网状结构腹侧部（MRF）的单单位和多单位活动，并对MPO、MD、IP、MRF、尾状核-壳核（CP）、缰核（HB）、背侧海马（HPC）、内侧和外侧隔区（m-和l-SEPT）以及外侧杏仁核（l-AMYG）施加单次或串脉冲刺激。在接受雌激素或雌激素和孕激素预处理的去卵巢大鼠中，于乌拉坦麻醉下记录单位活动。在去卵巢且经雌激素预处理的大鼠中，MPO单位对MRF、HB和l-SEPT的刺激表现出易化反应，对MD、HPC、m-SEPT和l-AMYG的刺激表现出抑制反应。CP刺激抑制MD单位活动。IP刺激对MPO或MD单位无影响，而IP单位受MPO、MD、CP和HB刺激的影响。MRF单位受MD和CP加速，受MPO刺激抑制。在去卵巢、经雌激素和孕激素处理的大鼠中，MPO单位对MRF和MD刺激的反应，以及MD单位对MRF和CP刺激的反应与仅接受雌激素处理的大鼠不同。此外，在去卵巢且经雌激素预处理的大鼠中，向MD局部应用孕激素可防止MD对MPO单位的抑制作用。当将孕激素给予受刺激的脑区时，它可加速受MRF刺激激活的MPO单位，并抑制受CP刺激抑制的MD神经元。多单位记录显示了类似结果。此外，全身应用孕激素后，HB和IP中的多单位活动增强。基于这些结果，讨论了大脑中参与脊柱前凸控制机制的可能神经网络。
