Gresson C R, Simpson F O
Br J Exp Pathol. 1974 Oct;55(5):519-23.
Plasma volume was measured and the severity of gross polyarteritis in the mesenteric vasculature assessed in groups of normotensive and hypertensive rats. Three groups of hypertensive rats were investigated: genetically hypertensive rats of the New Zealand strain, and renal hypertensive rats with one renal artery “clipped” and the opposite kidney either left intact or excised. Polyarteritis of varying severity developed in the mesenteric vasculature in many hypertensive rats, particularly the older ones. No vascular lesions visible to the naked eye were found in the normotensive rats. In rats with moderate to severe polyarteritis plasma volume was increased. Gross dilatation, both generalized and aneurysmal, of the mesenteric arterial tree in affected animals was demonstrated by means of silicone rubber casts. Presumably this and the secondary vascularization of the thickened wall of affected vessels cause an expansion of the intravascular space in rats with polyarteritis and this is a probable factor in the increased plasma volume found in these rats.
测量了正常血压和高血压大鼠组的血浆容量，并评估了肠系膜血管中严重结节性多动脉炎的程度。研究了三组高血压大鼠：新西兰品系的遗传性高血压大鼠，以及一侧肾动脉“夹闭”且另一侧肾脏完整或切除的肾性高血压大鼠。许多高血压大鼠，尤其是老年大鼠，肠系膜血管中出现了不同程度的多动脉炎。正常血压大鼠未发现肉眼可见的血管病变。在患有中度至重度多动脉炎的大鼠中，血浆容量增加。通过硅橡胶铸型显示，受影响动物的肠系膜动脉树普遍扩张和动脉瘤样扩张。据推测，这以及受影响血管增厚壁的继发性血管形成导致多动脉炎大鼠血管内空间扩大，这可能是这些大鼠血浆容量增加的一个因素。
