前列腺素C对猫和狗的心血管作用。
Cardiovascular actions of prostaglandin C in the cat and dog.
作者信息
Jones R L, Kane K A, Ungar A
出版信息
Br J Pharmacol. 1974 Jun;51(2):157-60. doi: 10.1111/j.1476-5381.1974.tb09642.x.
Abstract
1 Prostaglandin C(2) causes a prolonged fall in arterial blood pressure in the cat.2 At constant heart rate this fall in arterial pressure is accompanied by falls in stroke volume, left ventricular end diastolic pressure, and left ventricular dP/dt max.3 If mean aortic pressure and left ventricular end diastolic pressure are held constant as well as heart rate, prostaglandins C(2) and E(2) do not affect dP/dt max in the cat.4 In the dog, under similarly controlled conditions, prostaglandins C(2) and E(2) raise dP/dt max.5 We conclude that prostaglandins E(2) and C(2) have no direct inotropic action in the cat, but both have a direct positive inotropic action in the dog.
摘要
前列腺素C(2)可使猫的动脉血压出现长时间下降。
在心率恒定的情况下，动脉压的这种下降伴随着每搏输出量、左心室舒张末期压力以及左心室dP/dt最大值的下降。
如果平均主动脉压、左心室舒张末期压力以及心率保持恒定，前列腺素C(2)和E(2)对猫的dP/dt最大值没有影响。
在狗身上，在类似的控制条件下，前列腺素C(2)和E(2)会提高dP/dt最大值。
我们得出结论，前列腺素E(2)和C(2)对猫没有直接的变力作用，但对狗都有直接的正性变力作用。
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