前列腺素E2对正常血压和自发性高血压大鼠动脉血压的影响。
The effect of prostaglandin E2 on the arterial blood pressure of normotensive and spontaneously hypertensive rats.
作者信息
Simpson L L
出版信息
Br J Pharmacol. 1974 Aug;51(4):559-64. doi: 10.1111/j.1476-5381.1974.tb09674.x.
1 In anaesthetized rats, injection of prostaglandin E(2) (0.5-5.0 mug/kg i.v.) caused a dose-dependent vasodepressor response. The magnitude of response was significantly greater in spontaneously hypertensive rats than in normotensive rats.2 In spontaneously hypertensive rats, the magnitude of the prostaglandin-induced depressor response was closely correlated with blood pressure. The higher the blood pressure, the greater was the response evoked by prostaglandin.3 In spontaneously hypertensive rats, a combination of guanethidine plus hydralazine reduced both blood pressure and prostaglandin-induced depressor responses.4 Spontaneously hypertensive rats and normotensive rats did not differ in the magnitude of their vasodepressor responses to intravenously administered acetylcholine or isoprenaline.
在麻醉大鼠中，静脉注射前列腺素E(2)（0.5 - 5.0微克/千克）可引起剂量依赖性的血管减压反应。自发性高血压大鼠的反应幅度明显大于正常血压大鼠。
在自发性高血压大鼠中，前列腺素诱导的减压反应幅度与血压密切相关。血压越高，前列腺素引起的反应就越大。
在自发性高血压大鼠中，胍乙啶加肼屈嗪的联合使用降低了血压和前列腺素诱导的减压反应。
自发性高血压大鼠和正常血压大鼠对静脉注射乙酰胆碱或异丙肾上腺素的血管减压反应幅度没有差异。
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