Halliday J, Moir A T
Br J Pharmacol. 1974 Sep;52(1):27-34. doi: 10.1111/j.1476-5381.1974.tb09683.x.
1 A technique has been developed for open-ended perfusion of the cerebroventricular system of the unanaesthetized dog.2 Perfusion with an artificial CSF solution containing inulin and (42)K allowed the potassium fluxes out of and into the CSF to be monitored over a period of 2 to 3 hours.3 Sodium thiopentone and sodium pentobarbitone, in doses producing light anaesthesia, caused varying degrees of depression (up to 50%) in the CSF potassium fluxes, influx being consistently more affected than efflux. These effects are attributed to a decrease in the potassium exchange between extracellular and intracellular compartments in the brain.4 Diazepam depressed both potassium fluxes by up to 10% while there was some evidence that diphenylhydantoin depressed only potassium influx.5 Paraldehyde, in contrast to the other drugs, when given at a dose level sufficient to produce light anaesthesia, stimulated CSF potassium fluxes, particularly efflux.
已开发出一种用于对未麻醉犬的脑室系统进行开放式灌注的技术。
用含有菊粉和⁴²K的人工脑脊液溶液进行灌注，可在2至3小时内监测钾进出脑脊液的通量。
硫喷妥钠和戊巴比妥钠，在产生轻度麻醉的剂量下，会使脑脊液钾通量出现不同程度的降低（高达50%），流入始终比流出受影响更大。这些影响归因于大脑细胞外和细胞内区室之间钾交换的减少。
地西泮使两种钾通量均降低多达10%，而有一些证据表明苯妥英仅使钾流入降低。
与其他药物相反，副醛在给予足以产生轻度麻醉的剂量水平时，会刺激脑脊液钾通量，尤其是流出。
