Kalsner S
Can J Physiol Pharmacol. 1979 Mar;57(3):291-7. doi: 10.1139/y79-043.
The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary complications and the efects of periarterial nerve activation on coronary perfusion pressure were examined. It was found that stimulation induced vasoconstrictor responses which were enhanced by physostigmine, a cholinesterase inhibitor, and blocked by atropine. These responses were duplicated by exogenous acetylcholine both in the perfused preparation and in isolated strips of coronary artery. Although added noradrenaline gave vasodilatation, no response attributable to the release of noradrenaline from nerves was obtained. It is concluded that the coronary vasculature of the beef receives a cholinergic innervation and that its activation, especially under conditions of reduced transmitter degradation, may induce considerable coronary vessel constriction.
由于心肌动力学改变会引发并发症，而这些改变本身又会影响血流量，所以外在神经刺激对冠状动脉张力的直接影响尚不清楚。在本实验中，使用了一块分离并灌注的非搏动性牛肉心室平板，以消除继发性并发症，并研究动脉周围神经激活对冠状动脉灌注压的影响。结果发现，刺激可诱发血管收缩反应，该反应可被胆碱酯酶抑制剂毒扁豆碱增强，并被阿托品阻断。在灌注制剂和离体冠状动脉条中，外源性乙酰胆碱均可重复这些反应。虽然添加去甲肾上腺素会引起血管舒张，但未观察到可归因于神经释放去甲肾上腺素的反应。得出的结论是，牛肉的冠状动脉接受胆碱能神经支配，并且其激活，尤其是在递质降解减少的情况下，可能会导致冠状动脉明显收缩。
