Ferrant A, Lewis S M, Szur L
J Clin Pathol. 1974 Dec;27(12):983-5. doi: 10.1136/jcp.27.12.983.
Technetium-labelled erythrocytes provide a satisfactory agent for the measurement of red-cell volume with the advantages that there is a low radiation dose and repeated measurements can be readily carried out. A method of labelling red cells using (99)Tc(m)O(4) (-) with a small amount of stannous chloride has been evaluated in 20 patients, and compared with measurements of red-cell volume with (51)Cr-labelled erythrocytes carried out simultaneously in the same subjects. No significant differences between the results by either method occurred if the period of observation was limited to 20 minutes after the injection of labelled cells. Thereafter, elution of Tc from the cells made the determination of red-cell volume with (99)Tc(m) less reliable. Accordingly, the use of (99)Tc(m) as the label for red-cell volume measurements will result in errors if mixing of the erythrocyte pool is delayed, unless an elution correction factor is applied.
锝标记的红细胞为测量红细胞容量提供了一种令人满意的试剂，其优点是辐射剂量低且可轻松进行重复测量。已对20名患者评估了一种使用少量氯化亚锡与（99）Tc（m）O4（-）标记红细胞的方法，并与在同一受试者中同时进行的用（51）Cr标记红细胞测量红细胞容量的结果进行了比较。如果观察期限于注射标记细胞后20分钟，则两种方法的结果之间无显著差异。此后，细胞中Tc的洗脱使得用（99）Tc（m）测定红细胞容量的可靠性降低。因此，如果红细胞池的混合延迟，除非应用洗脱校正因子，否则使用（99）Tc（m）作为红细胞容量测量的标记将导致误差。
