Sasaki T, Yamamoto M
Cancer Res. 1979 Jul;39(7 Pt 1):2751-4.
Young mice chronically treated with beta-aminopropionitrile (BAPN) were subsequently given injections of graded doses of isoproterenol, and the response of various tissues to IPR in synthesizing DNA was analyzed. The results indicate that chronic administration of BAPN potentiates the effect of IPR for inducing DNA synthesis in the parotid, submandibular gland, kidney, and urinary bladder. The effect of BAPN was most pronounced in the submandibular gland. Namely, acinar cells in the submandibular gland normally respond less to IPR than do those in the parotid but respond more when mice have been treated with BAPN. It was suggested that the structural modification of collagen may counteract the blockage of events leading to DNA synthesis in epithelial cells in vivo.
对幼年小鼠长期给予β-氨基丙腈（BAPN）处理，随后注射不同剂量的异丙肾上腺素，并分析各种组织对异丙肾上腺素在合成DNA方面的反应。结果表明，长期给予BAPN可增强异丙肾上腺素诱导腮腺、下颌下腺、肾脏和膀胱中DNA合成的作用。BAPN的作用在下颌下腺最为明显。也就是说，下颌下腺的腺泡细胞通常对异丙肾上腺素的反应比腮腺中的腺泡细胞小，但在用BAPN处理过的小鼠中反应更大。有人认为，胶原蛋白的结构改变可能抵消体内上皮细胞中导致DNA合成的事件的阻滞。
