Malamud D, Chiu H
Horm Metab Res. 1978 Jul;10(4):340-3. doi: 10.1055/s-0028-1093427.
A single injection of isoproterenol (IPR) stimulates cell proliferation in rodent salivary glands after a lag period of about 24 hrs. Among the many events occurring prior to stimulated DNA synthesis, there is an early increase in cAMP levels and elevated transport of amino acids into the parotid gland. Amino acid transport is also elevated in liver and pancreas, tissues not induced to proliferate by IPR. IPR-stimulated alpha-aminoisobutyric acid (AIB) transport in parotid, pancreas and liver is augmented by prior injection of theophylline and is mimicked by dibutyryl cAMP. In all three tissues, changes in cAMP levels and subsequent increases in AIB transport appear to be closely related events. Since only the parotid gland is stimulated to grow after IPR injection, amino acid transport and growth would not appear to be directly related.
单次注射异丙肾上腺素（IPR）约24小时的延迟期后可刺激啮齿动物唾液腺中的细胞增殖。在刺激DNA合成之前发生的众多事件中，cAMP水平会早期升高，且氨基酸向腮腺的转运增加。肝脏和胰腺中氨基酸转运也会升高，而这些组织不会被IPR诱导增殖。预先注射茶碱可增强IPR刺激的腮腺、胰腺和肝脏中的α-氨基异丁酸（AIB）转运，且二丁酰cAMP可模拟该作用。在所有这三种组织中，cAMP水平的变化以及随后AIB转运的增加似乎是密切相关的事件。由于IPR注射后只有腮腺被刺激生长，因此氨基酸转运和生长似乎并非直接相关。
