Schmidt H D, Hoppe H, Heidenreich L
Cardiology. 1979;64(3):133-48. doi: 10.1159/000170611.
In 31 canine heart-lung preparations the direct cardiac effects of dopamine were compared to those of norepinephrine and orciprenaline. All three agents increased heart rate by 50-60% to a maximum of 240-250 beats/min. The inotropic effects of the three drugs were not significantly different. Even with the highest doses cardiac arrhythmias were rarely observed. To achieve maximal chronotropic and inotropic effects, dopamine required four times higher doses than norepinephrine and orciprenaline. All three drugs increased right ventricular dP/dt max by about twice as much as left ventricular dP/dt max. Peak systolic pressure (P max) in the right ventricle was increased 4-5 times more than P max in the left ventricle while mean aortic pressure was elevated by 12-16 mm Hg and mean pulmonary pressure by 6-14 mm Hg. The positive inotropic effect of all three sympathomimetics and of CaCl2 was substantially more pronounced on the right than on the left ventricle.
在31个犬心肺制备标本中，比较了多巴胺与去甲肾上腺素和奥西那林对心脏的直接作用。所有这三种药物均可使心率增加50% - 60%，最高可达240 - 250次/分钟。这三种药物的正性肌力作用无显著差异。即使使用最高剂量，也很少观察到心律失常。为达到最大变时性和变力性作用，多巴胺所需剂量是去甲肾上腺素和奥西那林的四倍。所有这三种药物使右心室dP/dt max增加的幅度约为左心室dP/dt max的两倍。右心室的收缩压峰值（P max）比左心室的P max升高4 - 5倍，而平均主动脉压升高12 - 16 mmHg，平均肺动脉压升高6 - 14 mmHg。所有这三种拟交感神经药和氯化钙的正性肌力作用在右心室比在左心室明显得多。
