Gillespie J S, McGrath J C
Br J Pharmacol. 1974 Dec;52(4):585-90. doi: 10.1111/j.1476-5381.1974.tb09727.x.
1 The depletion of noradrenaline (NA) in the rat anococcygeus muscle and vas deferens by reserpine and the effect on this of the abolition of nerve activity by pithing and reinforcement of nerve activity by stimulation of the spinal cord outflows has been studied.2 NA depletion of the anococcygeus and vas deferens measured 24 h after reserpine was similar and was related to dose. The heart was depleted faster than the two smooth muscle tissues.3 In the absence of reserpine neither abolition of nerve activity by pithing nor its reinforcement by nerve stimulation had a detectable influence on NA content of the anococcygeus or vas deferens.4 In rats given reserpine (200 mug/kg), increasing nerve activity by spinal stimulation significantly increased NA depletion in both the anococcygeus and the vas deferens when compared with animals pithed but not stimulated. These results confirm that nerve impulse traffic can be an important factor in determining the rate of depletion of NA by reserpine.5 The mechanical response to nerve stimulation in both the vas deferens and anococcygeus was resistant to quite severe depletion of their NA content, with the exception of the initial fast component of the response in the vas. The implications of these results for motor transmission in the vas deferens are discussed.
1 研究了利血平对大鼠肛尾肌和输精管中去甲肾上腺素（NA）的耗竭作用，以及通过脊髓切断消除神经活动和刺激脊髓传出神经增强神经活动对此的影响。2 利血平给药24小时后，肛尾肌和输精管中NA的耗竭情况相似，且与剂量相关。心脏中NA的耗竭速度比这两种平滑肌组织更快。3 在没有利血平的情况下，脊髓切断消除神经活动或神经刺激增强神经活动对肛尾肌或输精管中的NA含量均无明显影响。4 给大鼠注射利血平（200微克/千克）后，与脊髓切断但未受刺激的动物相比，通过脊髓刺激增加神经活动可显著增加肛尾肌和输精管中NA的耗竭。这些结果证实，神经冲动传导可能是决定利血平导致NA耗竭速度的一个重要因素。5 除输精管反应最初的快速成分外，输精管和肛尾肌对神经刺激的机械反应对其NA含量的相当严重的耗竭具有抗性。讨论了这些结果对输精管运动传递的意义。
