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乙酰胆碱超敏反应在刺激豚鼠回肠产生吗啡耐受性中的作用。

The role of supersensitivity to acetyl- choline in the production of tolerance to morphine in stimulated guinea-pig ileum.

作者信息

Shoham S, Weinstock M

出版信息

Br J Pharmacol. 1974 Dec;52(4):597-603. doi: 10.1111/j.1476-5381.1974.tb09729.x.

DOI:10.1111/j.1476-5381.1974.tb09729.x
PMID:4455335
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776882/
Abstract

1 Morphine caused a dose-dependent reduction in both the height of contraction and acetylcholine release from coaxially stimulated strips of guinea-pig ileum.2 Exposure of the tissue to morphine for 90 min produced acute tolerance to the effect of subsequent doses of morphine on contraction height.3 There was no change in the ability of morphine to suppress acetylcholine release.4 The responses of morphine-tolerant ileum to exogenous acetylcholine were enhanced 3 to 10-fold.5 If the ileum did not show tolerance to morphine it did not become more sensitive to acetylcholine.6 The results presented suggest that tolerance to morphine could result from a form of disuse supersensitivity.

摘要

  1. 吗啡使豚鼠回肠同轴刺激条的收缩高度和乙酰胆碱释放呈剂量依赖性降低。

  2. 将组织暴露于吗啡90分钟可产生对后续剂量吗啡对收缩高度影响的急性耐受性。

  3. 吗啡抑制乙酰胆碱释放的能力没有变化。

  4. 对吗啡耐受的回肠对外源性乙酰胆碱的反应增强了3至10倍。

  5. 如果回肠对吗啡未表现出耐受性，它对外源性乙酰胆碱就不会变得更敏感。

  6. 所呈现的结果表明，对吗啡的耐受性可能源于一种废用性超敏反应。

相似文献

1
The role of supersensitivity to acetyl- choline in the production of tolerance to morphine in stimulated guinea-pig ileum.乙酰胆碱超敏反应在刺激豚鼠回肠产生吗啡耐受性中的作用。
Br J Pharmacol. 1974 Dec;52(4):597-603. doi: 10.1111/j.1476-5381.1974.tb09729.x.
2
Nature of seasonal variation in development of acute tolerance to morphine.
Eur J Pharmacol. 1977 May 15;43(2):153-61. doi: 10.1016/0014-2999(77)90127-3.
3
Effect of morphine and acetylcholine on contractile activity and cyclic AMP in guinea-pig ileum.吗啡和乙酰胆碱对豚鼠回肠收缩活性及环磷酸腺苷的影响。
Biosci Rep. 1990 Feb;10(1):113-9. doi: 10.1007/BF01116859.
4
Effects of some cholinergic drugs on the actions of morphine on the ileum of the guinea-pig in vitro.某些胆碱能药物对吗啡在豚鼠离体回肠上作用的影响。
Arch Int Pharmacodyn Ther. 1975 May;215(1):13-9.
5
An analysis of the phenomenon of acute tolerance to morphine in the guinea-pig isolated ileum.豚鼠离体回肠对吗啡急性耐受性现象的分析。
Br J Pharmacol. 1975 Jan;53(1):131-8. doi: 10.1111/j.1476-5381.1975.tb07340.x.
6
The effect of morphine pretreatment on the sensitivity of mouse and guinea-pig ileum to acetylcholine and to morphine.
J Pharm Pharmacol. 1972 Jan;24(1):47-52. doi: 10.1111/j.2042-7158.1972.tb08863.x.
7
The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.豚鼠肠道和纵肌条释放的乙酰胆碱的来源。
J Physiol. 1968 Jan;194(1):13-33. doi: 10.1113/jphysiol.1968.sp008392.
8
The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956.吗啡及相关物质对同轴刺激的豚鼠回肠收缩和乙酰胆碱释放的作用。1956年。
Br J Pharmacol. 1997 Feb;120(4 Suppl):123-31; discussion 121-2. doi: 10.1111/j.1476-5381.1997.tb06787.x.
9
Further observations on the relaxant effect of caerulein on the guinea-pig ileum.关于蛙皮素对豚鼠回肠松弛作用的进一步观察
J Pharm Pharmacol. 1974 Jun;26(6):461-2. doi: 10.1111/j.2042-7158.1974.tb09316.x.
10
Morphine-tolerant longitudinal muscle strip from guinea-pig ileum.豚鼠回肠的吗啡耐受纵向肌条
Br J Pharmacol. 1973 Aug;48(4):655-66. doi: 10.1111/j.1476-5381.1973.tb08254.x.

引用本文的文献

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Pharmacological characterization of opiate physical dependence in the isolated ileum of the guinea-pig.豚鼠离体回肠中阿片类物质身体依赖性的药理学特性
Br J Pharmacol. 1981 Aug;73(4):859-66. doi: 10.1111/j.1476-5381.1981.tb08739.x.
2
Log dose/response curve flattening in rats after daily injection of opiates.大鼠每日注射阿片类药物后对数剂量/反应曲线的平坦化
Psychopharmacology (Berl). 1980;71(1):51-61. doi: 10.1007/BF00433252.
3
Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment.
Naunyn Schmiedebergs Arch Pharmacol. 1976;293(1):101-3. doi: 10.1007/BF00498877.
4
Sensitivity of mouse vas deferens to neurotransmitters: changes after morphine treatment.小鼠输精管对神经递质的敏感性：吗啡处理后的变化
Br J Pharmacol. 1979 Apr;65(4):623-8. doi: 10.1111/j.1476-5381.1979.tb07873.x.

本文引用的文献

1
DEPRESSION BY MORPHINE AND CHLORALOSE OF ACETYLCHOLINE RELEASE FROM THE CAT'S BRAIN.吗啡和水合氯醛对猫脑乙酰胆碱释放的抑制作用
J Physiol. 1965 Apr;177(3):411-9. doi: 10.1113/jphysiol.1965.sp007600.
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A GENERAL THEORY OF THE GENESIS OF DRUG DEPENDENCE BY INDUCTION OF RECEPTORS.通过诱导受体产生药物依赖性的一般理论。
Nature. 1965 Jan 9;205:181-2. doi: 10.1038/205181a0.
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The inhibition by morphine of the action of smooth muscle stimulants on the guinea-pig intestine.吗啡对平滑肌兴奋剂作用于豚鼠肠道的抑制作用。
Br J Pharmacol Chemother. 1960 Sep;15(3):425-31. doi: 10.1111/j.1476-5381.1960.tb01267.x.
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The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.吗啡及相关物质对同轴刺激的豚鼠回肠收缩和乙酰胆碱释放的作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):119-27. doi: 10.1111/j.1476-5381.1957.tb01373.x.
5
Inhibition by morphine of the release of acetylcholine from the intestine of the guinea-pig.吗啡对豚鼠肠道乙酰胆碱释放的抑制作用。
Br J Pharmacol Chemother. 1957 Mar;12(1):115-8. doi: 10.1111/j.1476-5381.1957.tb01372.x.
6
The effect of analgesic drugs on the release of acetylcholine from electrically stimulated guinea-pig ileum.镇痛药对电刺激豚鼠回肠乙酰胆碱释放的影响。
Br J Pharmacol Chemother. 1966 May;27(1):81-92. doi: 10.1111/j.1476-5381.1966.tb01643.x.
7
Acute tolerance to morphine following systemic and intracerebral injection in the rat.大鼠全身及脑内注射吗啡后的急性耐受性
Int J Neuropharmacol. 1966 Jan;5(1):35-42. doi: 10.1016/0028-3908(66)90049-9.
8
Effects of morphine and its antagonists on release of cerebral cortical acetylcholine.吗啡及其拮抗剂对大脑皮质乙酰胆碱释放的影响。
Nature. 1970 Oct 10;228(5267):176-7. doi: 10.1038/228176a0.
9
Nonspecific supersensitivity of the guinea-pig vas deferens produced by decentralization and reserpine treatment.去神经支配和利血平处理引起的豚鼠输精管非特异性超敏反应
Br J Pharmacol. 1970 May;39(1):110-20. doi: 10.1111/j.1476-5381.1970.tb09560.x.
10
Comparison of effect of morphine-like analgesics on transmurally stimulated guinea-pig ileum.吗啡样镇痛药对经壁刺激的豚鼠回肠作用的比较。
Br J Pharmacol. 1969 Oct;37(2):436-49. doi: 10.1111/j.1476-5381.1969.tb10580.x.