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长期隔离诱导大鼠对异丙肾上腺素产生超敏反应。

Supersensitivity to isoprenaline induced in rats by prolonged isolation.

作者信息

Speiser Z, Weinstock M

出版信息

Br J Pharmacol. 1974 Dec;52(4):605-8. doi: 10.1111/j.1476-5381.1974.tb09730.x.

DOI:10.1111/j.1476-5381.1974.tb09730.x
PMID:4455336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776898/
Abstract

1 The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6-8 weeks after weaning, and compared with its effect in group-housed litter-mate controls.2 Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate.3 Low doses of noradrenaline (5-10 ng) caused vasodepressor responses in isolated, but not in group-housed rats.4 The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group-housed controls by (+/-)-propranolol.5 Prolonged isolation of rats may bring about an increase in sensitivity of beta-adrenoceptors to isoprenaline and noradrenaline.

摘要

  1. 在断奶后单独饲养6 - 8周的麻醉雄性大鼠中测定异丙肾上腺素对舒张压和心率的影响，并将其与同窝分组饲养的对照大鼠的影响进行比较。

  2. 异丙肾上腺素使单独饲养的大鼠舒张压显著下降更多，心率增加更多。

  3. 低剂量去甲肾上腺素（5 - 10纳克）在单独饲养的大鼠中引起血管减压反应，但在分组饲养的大鼠中未引起。

  4. 单独饲养的大鼠对去甲肾上腺素的升压反应较小，通过（±）-普萘洛尔可将其增加到分组饲养对照大鼠的水平。

  5. 长期隔离大鼠可能会导致β-肾上腺素能受体对异丙肾上腺素和去甲肾上腺素的敏感性增加。

相似文献

1
Supersensitivity to isoprenaline induced in rats by prolonged isolation.长期隔离诱导大鼠对异丙肾上腺素产生超敏反应。
Br J Pharmacol. 1974 Dec;52(4):605-8. doi: 10.1111/j.1476-5381.1974.tb09730.x.
2
The effect of catecholamine infusions on myocardial blood flow, metabolic heat production and on general haemodynamics, before and after alprenolol (H56-28), in anaesthetized cats.在麻醉猫中，观察了阿普洛尔（H56 - 28）给药前后，儿茶酚胺输注对心肌血流量、代谢产热及整体血流动力学的影响。
Br J Pharmacol. 1970 May;38(3):554-71. doi: 10.1111/j.1476-5381.1970.tb10597.x.
3
Downregulation of propranolol-sensitive beta-adrenoceptor signaling after inhibition of nitric oxide synthesis.一氧化氮合成受抑制后普萘洛尔敏感的β-肾上腺素能受体信号通路的下调
Br J Pharmacol. 2006 Apr;147(7):755-64. doi: 10.1038/sj.bjp.0706675.
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Influence of propranolol and pindolol on the haemodynamic effects of papaverine, isoprenaline and noradrenaline in hypertensive patients.普萘洛尔和吲哚洛尔对高血压患者罂粟碱、异丙肾上腺素及去甲肾上腺素血流动力学效应的影响
Eur J Clin Pharmacol. 1980 Aug;18(2):141-6. doi: 10.1007/BF00561581.
5
Interaction of cholecystokinin (CCK-33) and its C-terminal fragments: CCK-8 and CCK-4 with alpha- and beta-adrenoceptor agonists and antagonists in the cardiovascular system of rats. Part A.胆囊收缩素（CCK - 33）及其C末端片段：CCK - 8和CCK - 4与α和β肾上腺素能受体激动剂及拮抗剂在大鼠心血管系统中的相互作用。A部分
Pol J Pharmacol. 1998 May-Jun;50(3):203-12.
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Chronotropic and inotropic effects of isoprenaline and L-noradrenaline in the dog heart.异丙肾上腺素和左旋去甲肾上腺素对犬心脏的变时性和变力性作用。
J Physiol. 1968 May;196(2):109P-110P.
7
Heart rate and blood pressure responses to intravenous boluses of isoprenaline in the presence of propranolol, practolol and atropine.在普萘洛尔、心得宁和阿托品存在的情况下，静脉注射异丙肾上腺素后的心率和血压反应。
Br J Clin Pharmacol. 1983 Aug;16(2):175-84. doi: 10.1111/j.1365-2125.1983.tb04982.x.
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Effects of footshock stress on the sensitivity of the isolated rat pacemaker to catecholamines.足部电击应激对离体大鼠起搏器对儿茶酚胺敏感性的影响。
Braz J Med Biol Res. 1987;20(3-4):467-70.
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The selectivity of beta-adrenoceptor antagonists on isoprenaline-induced changes in heart rate, blood pressure, soleus muscle contractility and airways function in anaesthetized cats.β-肾上腺素能拮抗剂对麻醉猫中异丙肾上腺素诱导的心率、血压、比目鱼肌收缩力和气道功能变化的选择性。
Br J Pharmacol. 1983 Oct;80(2):323-34. doi: 10.1111/j.1476-5381.1983.tb10037.x.
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The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol.β-肾上腺素能受体部分激动剂奥昔非君长期口服给药的血流动力学效应：与普萘洛尔的比较。
Br J Pharmacol. 1974 May;51(1):5-13. doi: 10.1111/j.1476-5381.1974.tb09625.x.

引用本文的文献

1
Changes in brain catecholamine turnover and receptor sensitivity induced by social deprivation in rats.
Psychopharmacology (Berl). 1978 Mar 1;56(2):205-9. doi: 10.1007/BF00431851.

本文引用的文献

1
Effect of grouping on the level of brain norepinephrine in white Swiss mice.分组对瑞士小白鼠脑去甲肾上腺素水平的影响。
Life Sci. 1965 May;4(9):1011-8. doi: 10.1016/0024-3205(65)90205-5.
2
The "isolation syndrome" in mice.小鼠的“隔离综合征”。
Psychopharmacologia. 1973 Aug 3;31(4):305-20. doi: 10.1007/BF00421275.
3
Greater lowering of brain and adrenal catecholamines in group-housed than in individually-housed mice administered DL-alpha-methyltyrosine.与单独饲养的给予DL-α-甲基酪氨酸的小鼠相比，群居饲养的小鼠脑和肾上腺儿茶酚胺的降低幅度更大。
J Pharm Pharmacol. 1968 Mar;20(3):244-6. doi: 10.1111/j.2042-7158.1968.tb09734.x.
4
The effect of dl-propranolol, d-propranolol and practolol on the hyperactivity induced in rats by prolonged isolation.dl-普萘洛尔、d-普萘洛尔和美多心安对长期隔离诱导大鼠产生的多动行为的影响。
Psychopharmacologia. 1973 Jun 19;30(3):241-50. doi: 10.1007/BF00422870.