长期隔离诱导大鼠对异丙肾上腺素产生超敏反应。

Supersensitivity to isoprenaline induced in rats by prolonged isolation.

作者信息

Speiser Z, Weinstock M

出版信息

Br J Pharmacol. 1974 Dec;52(4):605-8. doi: 10.1111/j.1476-5381.1974.tb09730.x.

DOI:10.1111/j.1476-5381.1974.tb09730.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776898/

Abstract

1 The effect of isoprenaline on diastolic blood pressure and heart rate was determined in anaesthetized male rats which had been housed individually for 6-8 weeks after weaning, and compared with its effect in group-housed litter-mate controls.2 Isoprenaline caused a significantly greater fall in diastolic pressure in isolated rats and a greater increase in heart rate.3 Low doses of noradrenaline (5-10 ng) caused vasodepressor responses in isolated, but not in group-housed rats.4 The pressor response to noradrenaline, which was smaller in isolated rats, was increased to the level of group-housed controls by (+/-)-propranolol.5 Prolonged isolation of rats may bring about an increase in sensitivity of beta-adrenoceptors to isoprenaline and noradrenaline.

摘要

在断奶后单独饲养6 - 8周的麻醉雄性大鼠中测定异丙肾上腺素对舒张压和心率的影响，并将其与同窝分组饲养的对照大鼠的影响进行比较。
异丙肾上腺素使单独饲养的大鼠舒张压显著下降更多，心率增加更多。
低剂量去甲肾上腺素（5 - 10纳克）在单独饲养的大鼠中引起血管减压反应，但在分组饲养的大鼠中未引起。
单独饲养的大鼠对去甲肾上腺素的升压反应较小，通过（±）-普萘洛尔可将其增加到分组饲养对照大鼠的水平。
长期隔离大鼠可能会导致β-肾上腺素能受体对异丙肾上腺素和去甲肾上腺素的敏感性增加。

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Supersensitivity to isoprenaline induced in rats by prolonged isolation.长期隔离诱导大鼠对异丙肾上腺素产生超敏反应。

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引用本文的文献

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本文引用的文献

1

Effect of grouping on the level of brain norepinephrine in white Swiss mice.分组对瑞士小白鼠脑去甲肾上腺素水平的影响。

Life Sci. 1965 May;4(9):1011-8. doi: 10.1016/0024-3205(65)90205-5.

2

The "isolation syndrome" in mice.小鼠的“隔离综合征”。

Psychopharmacologia. 1973 Aug 3;31(4):305-20. doi: 10.1007/BF00421275.

3

Greater lowering of brain and adrenal catecholamines in group-housed than in individually-housed mice administered DL-alpha-methyltyrosine.与单独饲养的给予DL-α-甲基酪氨酸的小鼠相比，群居饲养的小鼠脑和肾上腺儿茶酚胺的降低幅度更大。

J Pharm Pharmacol. 1968 Mar;20(3):244-6. doi: 10.1111/j.2042-7158.1968.tb09734.x.

4

The effect of dl-propranolol, d-propranolol and practolol on the hyperactivity induced in rats by prolonged isolation.dl-普萘洛尔、d-普萘洛尔和美多心安对长期隔离诱导大鼠产生的多动行为的影响。

Psychopharmacologia. 1973 Jun 19;30(3):241-50. doi: 10.1007/BF00422870.

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