体外培养的晶状体上皮细胞中的组蛋白生物合成与周转
Histones biosynthesis and turnover in epithelial lens cells cultured in vitro.
作者信息
Hervé B, Jacquemin E, Courtois Y
出版信息
Cell Biol Int Rep. 1979 May;3(3):271-81. doi: 10.1016/0309-1651(79)90040-7.
PMID:445584
Abstract
"Histone synthesis was compared in epithelial lens cells during exponential growth and in the stationary phase brought by contact inhibition. Double labelling experiments with 3H-lysine and 14C-lysine show a net turnover of histone H1 independent of DNA replication. The nucleosome core histones seem to turn over also, but much more slowly than H1".
摘要
对指数生长期的晶状体上皮细胞以及接触抑制导致的静止期细胞中的组蛋白合成进行了比较。用³H-赖氨酸和¹⁴C-赖氨酸进行的双重标记实验表明，组蛋白H1的净周转与DNA复制无关。核小体核心组蛋白似乎也会周转，但比H1慢得多。
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