乙醇对大鼠肾上腺髓质的影响。
Effects of ethanol on the adrenal medulla of the rat.
作者信息
Pohorecky L A, Jaffe L S, Berkeley H A
出版信息
Pharmacology. 1974;12(6):340-6. doi: 10.1159/000136557.
These studies describe the effects of ethanol on the adrenal medulla of rats. Ethanol intake for 3 weeks in the form of a liquid diet increased catecholamine content by 14 percent; the increase was mainly due to a rise in epinephrine content. Concomitantly, there was a 16-percent increase in PNMT activity. On withdrawal of ethanol from the diet, catecholamine synthesis from 3-H-tyrosine was greatly stimulated; this effect and the behavioral symptoms of withdrawal could be partially prevented by giving an injection of ethanol. Gradual ethanol withdrawal from the diet did not lead to stimulation of the adrenal medulla.
这些研究描述了乙醇对大鼠肾上腺髓质的影响。以流质饮食形式摄入乙醇3周，使儿茶酚胺含量增加了14%；这种增加主要是由于肾上腺素含量的升高。同时，苯乙醇胺N-甲基转移酶（PNMT）活性增加了16%。当从饮食中撤除乙醇后，由3-H-酪氨酸合成儿茶酚胺的过程受到极大刺激；通过注射乙醇，这种效应以及戒断的行为症状可得到部分预防。从饮食中逐渐撤除乙醇不会导致肾上腺髓质受到刺激。
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