Lundsteen C, Granum E
Clin Genet. 1979 May;15(5):430-9.
Band transition profiles (BT-profiles) representing extracted band pattern features of 898 density profiles of banded chromosomes were classified and karyotyped by a cytogeneticist in order to investigate how much information was lost by substituting for the original density profiles their extracted features. The results were evaluated and compared with visual classification and karyotyping of the same 898 density profiles from which the BT-profiles were derived. Six per cent errors were made in classification of isolated BT-profiles and 0.7% errors were made in karyotyping BT-profiles. These error rates were comparable to the corresponding error rates in classifying and karyotyping density profiles, which were 5% and 0.5%, respectively. It is concluded that most of the important band pattern information of the density profiles is retained in the BT-profiles, and it is supposed that the condensed BT-sequences (from which the BT-profiles are derived) constitute a sufficient and appropriate basis for automated karyotyping.
为了研究用提取的特征替代带状染色体的原始密度轮廓会损失多少信息，一位细胞遗传学家对代表898个带状染色体密度轮廓提取的带型特征的带转换轮廓（BT轮廓）进行了分类和核型分析。对结果进行了评估，并与从中得出BT轮廓的相同898个密度轮廓的视觉分类和核型分析进行了比较。在孤立BT轮廓的分类中出现了6%的错误，在BT轮廓的核型分析中出现了0.7%的错误。这些错误率与密度轮廓分类和核型分析中的相应错误率相当，分别为5%和0.5%。得出的结论是，密度轮廓的大多数重要带型信息保留在BT轮廓中，并且推测浓缩的BT序列（从中得出BT轮廓）构成了自动核型分析的充分且合适的基础。
